en Psychiatry Psychiatry Original Research Original Research <strong>Background: </strong>COVID-19 (coronavirus disease 2019) pandemic has seriously affected the entire world. This study was aimed to assess prevalence and influencing factors of anxiety and depression during the pandemic in our Pakistani population, including healthcare professionals, undergraduate medical students, and general public.<br> <strong>Methods:</strong> An online cross sectional survey was conducted; with a questionnaire having demographic profile, COVID-19-related knowledge/awareness, self-rating anxiety scale (SAS), and self-rating depression scale (SDS). A total of 1014 people responded to the survey. Chi square test was used to compare different groups, and logistic regression models were used to explore influencing factors for anxiety and depression symptoms.<br> <strong>Results:</strong> Of the 1014 respondents, 92.6% were aware of COVID-19, and the prevalence rate of anxiety and depression symptoms was 4.6% and 14.3%, respectively. Healthcare professionals had more awareness about COVID-19 as compared to medical students and general public (p<0.001). Logistic regression models showed females, and people who were not aware of COVID-19 (&le; 6 points score) were more likely to have both anxiety and depression symptoms (p<0.05), the general public had more anxiety than healthcare professionals (p<0.05), while undergraduate medical students and young people had only depression (p<0.05).<br> <strong>&nbsp;&nbsp; Conclusion:</strong> Although major mental health burden is not present in Pakistan, but there is a dire need to pay more attention to vulnerable groups like young people, undergraduate medical students, and women. Psychological interventions are required to reduce the psychological impact of COVID-19 pandemic. Corona Virus Disease 2019 (COVID-19), Awareness, Anxiety, Depression, Mental health 900 907 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6097-1&slc_lang=en&sid=1 Sardar Muhammad Alfareed Zafar alfareedivf@hotmail.com 200319475328460064435 200319475328460064435 No Lahore General Hospital, & Ameer-ud-Din Medical College, Lahore, Punjab, Pakistan Muhammad Junaid Tahir junaid262626@gmail.com 200319475328460064436 200319475328460064436 Yes Lahore General Hospital, & Ameer-ud-Din Medical College, Lahore, Punjab, Pakistan Muna Malik mmkamboh@hotmail.com 200319475328460064437 200319475328460064437 No Lahore General Hospital, & Ameer-ud-Din Medical College, & Medical Microbiology & Infectious Diseases Society of Pakistan, Lahore, Punjab, Pakistan Muhammad Irfan Malik drmirfanmalik@hotmail.com 200319475328460064438 200319475328460064438 No Lahore General Hospital, & Ameer-ud-Din Medical College, & Pakistan Chest Society, & European Respiratory Society Lahore, Punjab, Pakistan Fahd Kamal Akhtar fkak82@gmail.com 200319475328460064439 200319475328460064439 No Lahore General Hospital, & Ameer-ud-Din Medical College, & Pakistan Oculoplastic Association & Ophthalmological Society of Pakistan, Lahore, Punjab, Pakistan Rubi Ghazala rubighazala@yahoo.com 200319475328460064440 200319475328460064440 No Lahore General Hospital, & Ameer-ud-Din Medical College, Lahore, Punjab, Pakistan