en Biological Sciences Biological Sciences Original Research: Basic Science in Medicine Original Research: Basic Science in Medicine To understand the mechanism of Multiple Sclerosis (MS), an autoimmune demyelinating disease, the researchers developed an experimental animal model for MS, which is called EAE (Experimental Allergic Encephalomyelitis). There are several methods for inducing this animal model. In this research the active EAE, which is developed by injecting bovine myelin antigens into genetically susceptible animals, was used. Proteolipid protein (PLP) , which is a prominent neuroantigen, was extracted from fresh bovine brain, and used for inducing EAE in female Balb/c and Guinea pig. Animals were weighed and examined daily for clinical symptoms. Also histological sections from EAE brains were prepared. These sections showed infiltration, congestion and demyelination. Multiple Sclerosis disease, EAE animal model, PLP. 245 249 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-148&slc_lang=en&sid=1 F ALASTI 20031947532846003755 20031947532846003755 No MH SANATI msanati@nrcgeb.ac.ir 20031947532846003756 20031947532846003756 Yes From the National Research Center for Genetic Engineering and Biotechnology (NRCGEB), Tehran, Iran