en Epidemiology Epidemiology Original Research Original Research <strong>Background: </strong>Human infection affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been recognized as a global health concern. We report the epidemiological and clinical characteristics of patients with a familial cluster of SARS-CoV-2 from Qazvin province (located in the northwest of Iran).<br> &nbsp;&nbsp; <strong>Methods:</strong> In this cross-sectional study, we enrolled 332 hospitalized patients that were confirmed SARS-CoV-2 diseases with laboratory-based (PT-PCR) test in Qazvin province, Iran. Having family infection transmission and subsequently, family clustering of SARS-COV-2 disease was assessed with the Generalized Estimating Equation model in patients.<br> &nbsp;&nbsp; <strong>Results:</strong> Crude odds ratio estimates of creating family clustering of SARS-CoV-2 infection was 0.47 times [95% CI: 0.23, 0.98, p=0.045] less for female compared to the males; 2.26 [95% CI: 1.11, 4.58, p=0.024] and 2.69 [95% CI: 1.47, 4.93, p=0.001] for SARS-CoV-2 patients that had digestive and muscle pain in comparison with those did not this mentioned symptoms, respectively. 1.52 [95% CI: 1.05, 2.23, p=0.024] for patients with a longer hospitalization compared with patients that had shorter duration of hospitalization and adjusted odds ratio estimates were 2.13 [95% CI: 1.12, 4.03, p=0.020] for patients who receive public health services in comparison those did not receive public health services.<br> &nbsp;&nbsp; <strong>Conclusion:</strong> Our findings confirm the person-to-person transmission of this novel coronavirus in family settings and hospitals, and the reports of infected travelers in other geographical regions. Major gaps in our knowledge about the potential factors in creating family clustering of SARS-CoV-2 infection, epidemiology, duration of human transmission and etc. need fulfillment by future studies. Epidemiology, SARS-CoV-2, COVID-19, Family Clustering, Close Contacts, Iran 224 226 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-3212-3&slc_lang=en&sid=1 Zahra Hosseinkhani z.hoseinkhani@qums.ac.ir 200319475328460068492 200319475328460068492 Yes Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran Zohreh Foroozanfar foroozanfar.zohre@gmail.com 200319475328460068493 200319475328460068493 No Shiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran Maryam Zamanian zamanian.m2015@gmail.com 200319475328460068494 200319475328460068494 No Department of Epidemiology, School of Health, Arak University of Medical Sciences, Arak, Iran Rahmatollah Moradzadeh moradzadehr@yahoo.com 200319475328460068495 200319475328460068495 No Department of Epidemiology, School of Health, Arak University of Medical Sciences, Arak, Iran Ali Ghandian A_ghandian56@yahoo.com 200319475328460068496 200319475328460068496 No Communicable disease office, Deputy of Health, Qazvin University of Medical Sciences, Qazvin, Iran Hamidreza Najari mrpthndr1382@yahoo.com 200319475328460068497 200319475328460068497 No Department of Infectious Diseases, Qazvin University of Medical Sciences, Qazvin, Iran Kazhal Mobaraki Mobaraki.k@umsu.ac.ir 200319475328460068498 200319475328460068498 No Social Determinants of Health Research Center, Urmia University of Medical Sciences, Urmia, Iran Jamal Ahmadzadeh ahmadzadeh.j@umsu.ac.ir 200319475328460068499 200319475328460068499 No Social Determinants of Health Research Center, Urmia University of Medical Sciences, Urmia, Iran Hadi Bagheri bagheri.hadi61@gmail.com 200319475328460068500 200319475328460068500 No Children Growth Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran