Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1399
10
1
gregorian
2021
1
1
35
1
online
1
fulltext
en
Histopathologic survey on lung necropsy specimens of 15 patients who died from COVID-19: A large study from Iran with a high rate of anthracosis
Pulmonary Disease
Pulmonary Disease
Original Research
Original Research
<strong>Background: </strong>In the pandemic era of Coronavirus disease 19 (COVID-19), one of the most important issues is the nature of real pathological events that occur during disease course in different parts of the body. There are several ways to know more about COVID-related histopathological events,such as tissue sampling which means biopsy from the tissues of either livepeople or necropsy/autopsy of people who died from COVID-19.<br>
<strong> Methods: </strong>We conducted an original study for assessing histopathological findings of lung necropsy samples collected from 15 Iranian patients.The continuous variables were presented as mean and standard deviation, and for the qualitative data on histopathological findings, the percentage or qualitative scores (0 to +3) were used.<br>
<strong> Results: </strong>We found similar presentations of COVID-related histopathologic events regarding percentage and severity in pulmonary tissue, includinglymphocytic infiltrations, inflammatory infiltrations of septal and perivascular areas, desquamated type2 pneumocytes, hyaline membrane changes, fibrin material depositions, abnormal changes of alveolar capillaries, presence of megakaryocytes, PMN infiltrations, septal necrosis, microabscess formation and bacterial colony formation. Also, we found few interesting features which were not completely compatible with previous similar studies or newly reported by ours asa high percentage of anthracosis (86%: 13 patients) that was not clearly reported in other previous studies, also a lower percentage of microthrombotic vascular lung injuries (20%: 3 patients), and a higher percentage of viral cytopathic effects (27%: 4 patients).<br>
<strong> Conclusion: </strong>This article suggests a greater need for evaluatingthe autopsy samples of COVID-19 patients to provide better management strategies and propose the question of whether anthracosismay be a mortality risk factor in COVID-19 patients.
COVID-19, Autopsy, Necropsy, Biopsy, Tissue Sampling, Histopathology, Lung, Anthracosis
481
490
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-3072-3&slc_lang=en&sid=1
Siavash
Kooranifar
kooranifar.s@iums.ac.ir
200319475328460063218
200319475328460063218
No
Department of Internal Medicine, School of Medicine, Rasool Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran
Alireza
Sadeghipour
Sadeghipour.ar@iums.ac.ir
200319475328460063219
200319475328460063219
No
Department of Pathology and Oncopathology Research Center, Rasool Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran
Taghi
Riahi
riahi.t@iums.ac.ir
200319475328460063220
200319475328460063220
Yes
Department of Internal Medicine, School of Medicine, Rasool Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran
Azadeh
Goodarzi
goodarzi.a@iums.ac.ir
200319475328460063221
200319475328460063221
No
Department of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran
Sanaz
Tabrizi
Tabrizi_537@yahoo.com
200319475328460063222
200319475328460063222
No
Department of Internal Medicine, School of Medicine, Rasool Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran
Navid
Davoody
dr.n.davoody@gmail.com
200319475328460063223
200319475328460063223
No
Department of Internal Medicine, School of Medicine, Rasool Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran