en Neurology Neurology Systematic Review <strong>Background: </strong>Diarrhea-associated-hemolytic-uremic-syndrome (D+HUS) is a common from of HUS. Central-nervous-system (CNS) involvement is one of the most common extrarenal organ involvements in children with D+HUS. This systematic review and meta-analysis aim to recognize the frequency of neurological complications in pts with HUS.<br> &nbsp;&nbsp; <strong>Methods: </strong>Databases of PubMed, Embase, and Web of Science were searched systematically to find the papers on neurological involvement in HUS pts. Two researchers independently assessed the papers&rsquo; quality and extracted data. CMA v. 2.2.064. was used for data analysis. Heterogeneity was evaluated using the I-squared (I2) test, and a fixed/random-effects model was used when appropriate.<br> &nbsp;&nbsp; <strong>Results: </strong>In this review, 21 studies including 2,189 participants with a median age between 1.3-40-year-old, entered the meta-analysis. The meta-analysis in D+HUS patients indicated 27.0% with neurological complications (95% CI, 22.0%-32.6%), 25.5% of symptoms weren&rsquo;t categorized (95% CI, 15.9%-38.3%), 20.8% of them developed the seizures (95% CI, 2.3%-74.4%). In D-HUS pts, 20.8% of them were presented neurological symptoms (95% CI, 17.9%-24.0%), of which 29.0% weren&rsquo;t categorized (95% CI, 19.2%-41.2%), 17.5% of pts got into coma (95% CI, 9.6%-29.7%), 5.6 % showed hemiparesis (95% CI, 2.8%-10.9%), 17.2% experienced lethargy (95% CI, 5.2%-44.1%), 30.5% developed the seizures (95% CI, 18.2%-46.2%), 7.4% manifested speech abnormalities (95% CI, 0.2%-7.22%), 6.4% of D-HUS pts presented visual-disturbances (95% CI, 3.4%-11.6%).<br> &nbsp;&nbsp; <strong>Conclusion:</strong> This systematic review and meta-analysis indicated more than one-fourth of both D+HUS and D-HUS patients were presented with neurological symptoms, and the most prevalent symptoms were seizures, which can lead to an epilepsy sequel.<br> &nbsp; HUS, CNS, Diarrhea, Neurological symptoms, Pediatrics, Adults 716 726 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6500-1&slc_lang=en&sid=1 Azita Tavasoli Azita_tavasoli@yahoo.com 200319475328460063078 200319475328460063078 No Ali-Asghar Children Hospital, Iran University of Medical and Sciences, Tehran, Iran Shahrbanoo Nakhaiee S.nakhaiee@yahoo.com 200319475328460063079 200319475328460063079 No Ali-Asghar Children Hospital, Iran University of Medical and Sciences, Tehran, Iran Nazanin Zafaranloo bbrokh@yahoo.com 200319475328460063080 200319475328460063080 No Ali-Asghar Children Hospital, Iran University of Medical and Sciences, Tehran, Iran Rozita Hoseini Rozitahoseini@yahoo.com 200319475328460063081 200319475328460063081 No Ali-Asghar Children Hospital, Iran University of Medical and Sciences, Tehran, Iran Hasan Otukesh Hasanotukesh@yahoo.com 200319475328460063082 200319475328460063082 No Ali-Asghar Children Hospital, Iran University of Medical and Sciences, Tehran, Iran Behnam Sobouti Sobouti.b@iums.ac.ir 200319475328460063083 200319475328460063083 Yes Ali-Asghar Children Hospital, Iran University of Medical and Sciences, Tehran, Iran