en COVID 19 Systematic Review <strong>Background: </strong>Given the various reports of the clinical spectrum of the disease, the aim of the present study was to determine possible scenarios of Coronavirus 2019 (COVID-19) iceberg using published articles.<br> &nbsp;&nbsp; <strong>Methods:</strong> The present study was a rapid review of all international databases, including PubMed (Medline), Scopus, Web of Sciences, Embase, and Cochrane Library from January 1 to October 30, 2020.<br> &nbsp;&nbsp; <strong>Results:</strong> In this review, 7 scenarios were considered for COVID-19 iceberg, in which the range of fatality percentage was estimated to be 0.5% to 7%, the range of asymptomatic cases 1% to 88.6%, the range of cases with mild symptoms 8% to 78%, no symptoms 1 % to 90 %, the range of intensive care unit (ICU) admission was 0.5% to 14.2%, and finally the intubation percentage was estimated to be 0.2% to 12.2%. The Scenarios Diamond Princess Cruise Ship and Iceland are closer to the reality of the clinical spectrum of COVID-19 around the world, which represent 0.6% and 0.5% of deaths, 0.7% and 1% of intubations, 2.5% and 9.7% of ICU admissions, 1.1% and 6% of hospitalizations, 15% and 31% of cases with mild symptoms, and finally 56.9% and 75% of asymptomatic cases of COVID-19, respectively, which should now be considered as the basis of the clinical knowledge of the disease.&nbsp;<br> &nbsp;&nbsp; <strong>Conclusion:</strong> Understanding the clinical spectrum and natural knowledge of the disease and paying attention to asymptomatic or mild-symptom cases can help to make better decisions and develop more effective interventions to control COVID-19.<br> <strong><span dir="RTL"></span></strong> Best Estimates, Iceberg, COVID 19, Clinical Spectrum, Natural Knowledge, Rapid Review 595 604 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1741-22&slc_lang=en&sid=1 Ghobad Moradi moradi_gh@yahoo.com 200319475328460063154 200319475328460063154 No Social Determinants of Health Research Center, Research Institute for Health Development, & Department of Epidemiology and Biostatistics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran Fatemeh Gholami gholamifatemeh734@gmail.com 200319475328460063155 200319475328460063155 No Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran Mohammad Aziz Rasouli rasouli1010@gmail.com 200319475328460063156 200319475328460063156 Yes Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran Fahimeh Bagheri Amiri Fahimehbagheri@yahoo.com 200319475328460063157 200319475328460063157 No Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Yousef Moradi yousefmoradi211@yahoo.com 200319475328460063158 200319475328460063158 No Social Determinants of Health Research Center, Research Institute for Health Development, & Department of Epidemiology and Biostatistics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran