Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1399
10
1
gregorian
2021
1
1
35
1
online
1
fulltext
en
Correlations between Specific and Nonspecific Vaginal Immunity in Women with Breast Cancer in Kazakhstan
Oncology
Oncology
Original Research
Original Research
<strong>Background: </strong>The most common malignant tumor in women is breast cancer (BC). The ability of regulatory cells to inhibit cellular immune response as well as to participate in the modulation of antitumor immunity has attracted much interest of scientists. The purpose of this study was to assess the correlation between the specific and nonspecific vaginal immunity in women with BC.<br>
<strong>Methods:</strong> This was an experimental study. The study involved 278 women, 174 of whom received chemotherapy. The sampling was performed using a universal probe. The qualitative and quantitative assessment of the vaginal microflora was done using the polymerase chain reaction method. Statistical processing of the analysis was performed using the Statistica 10.0 licensed software. The parameters of the immune status before and after chemotherapy were analyzed, and the correlation between the number of cells in the main populations of lymphocytes before and after chemotherapy was investigated.<br>
<strong>Results: </strong>The study of the correlation between the number of cells of the main lymphocyte populations before and after chemotherapy showed an inhibition of B-lymphocytes (CD3-CD19+) in the study group, as the subpopulations of T-cytotoxic (CD4-CD8+) and CD3+HLA-DR+ (activated E-lymphocytes) were increased in both groups. Direct correlations were observed between local vaginal immunity and the immune status of the examined women in the study group between Megasphaera spp. and Enterobacteriaceae, with a certain population of immunocompetent cells.<br>
<strong>Conclusion:</strong> It was concluded that impaired biocenosis and suppression of local immune responses in women with BC were the reason for the active involvement of the components of the immune system.
Malignant Neoplasms, Immunoediting, Vaginal Immunity, Normal Flora, Obligate Anaerobes, Biocenosis
1184
1189
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6643-2&slc_lang=en&sid=1
Ainur
Amanzholkyzy
amanzholkyzy5485@uoel.uk
200319475328460066824
200319475328460066824
No
Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Republic of Kazakhstan
Gulaim
Taskozhina
gulaim@nuos.pro
200319475328460066825
200319475328460066825
No
2. Department of Pathological Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan
Farida
Balmaganbetova
balmaganbetova5485@kpi.com.de
200319475328460066826
200319475328460066826
Yes
Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Republic of Kazakhstan
Azhar
Zhexenova
zhexenova5485@kpi.com.de
200319475328460066827
200319475328460066827
No
Department of Pathological Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan
Roza
Nurgaliyeva
rust3@tanu.pro
200319475328460066828
200319475328460066828
No
Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Republic of Kazakhstan