Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1400
10
1
gregorian
2022
1
1
36
1
online
1
fulltext
en
Correlation between Alkaline Phosphatase and Neonatal Jaundice
Neonatal
Neonatal
Original Research
Original Research
<span style="font-size:14px;"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><b><span style="font-style:normal">Background: </span></b><span style="font-style:normal">Hyperbilirubinemia is one of the most common neonatal disorders and one of the risk factors of neurological complications. So this study was conducted to evaluate the correlation between alkaline phosphatase (ALP) and pathological jaundice. </span></span></span><br>
<span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><span style="font-style:normal"> <b>Methods:</b> A case-control was performed on term neonates with and without pathological jaundice who were referred to the Hazrat-e-Ali Asghar Hospital in 2017. In both groups, cases (neonates with pathological jaundice, n=153) and control (neonates with and without pathological jaundice, n=153) levels of alkaline-phosphatase and serum total bilirubin were evaluated with biochemical tests. Moreover, other data were also recorded from their history and clinical examinations. In addition, the severity of jaundice, duration of hospitalization, type of required treatment, and probable complications after the treatment were considered in follow-up. Data were collected by checklist and entered to SPSS v.20. ALP level and its relationship with serum total bilirubin compared between two groups. </span></span></span><br>
<span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><span style="font-style:normal"> <b>Results: </b>Mean level of ALP was 411.3 ± 134.2 U/L in the case group and 338 ± 131.4 U/L in the control group. Serum total bilirubin level was 11.9 mg/dl in the case group and 6.2 mg/dl in the control group. ALP levels in the case group were significantly more than the control group (p=0.001). There was no correlation between ALP and serum total bilirubin level in neonates in the case group (p=0.532). There was no statistically significant relationship between alkaline phosphatase level and gender of neonates, but the relationship of ALP level with types of delivery was statistically significant (p=0.002). There was not a significant relationship between ALP level with hospitalization duration (p=0.371).</span></span></span><br>
<span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><span style="font-style:normal"> <b>Conclusion:</b> The result of this study showed that there is no correlation between ALP levels and pathological jaundice in patients, although this issue needs to be approved by the other studies. </span></span></span></span><br>
Pathological Jaundice, Alkaline Phosphatase, Serum Total Bilirubin Level, Neonate
380
383
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-5461-4&slc_lang=en&sid=1
Maryam
Saboute
saboute.m@iums.ac.ir
200319475328460069854
200319475328460069854
No
Department of Neonatology, Akbar Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran
Aco
Mahmoudian
Mahmoudian.A@yahoo.com
200319475328460069855
200319475328460069855
No
Department of Neonatology, Ali Asghar Hospital, Iran University of Medical Sciences, Tehran, Iran
Nasrin
Khalesi
khalesi.n@iums.ac.ir
200319475328460069856
200319475328460069856
Yes
Department of Neonatology, Ali Asghar Hospital, Iran University of Medical Sciences, Tehran, Iran
Zahra
Vahedi
vahedi.z@Iums.ac.ir
200319475328460069857
200319475328460069857
No
Pediatric Department, Firooz Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran
Nastaran
Khosravi
nastarankhosravi@yahoo.com
200319475328460069858
200319475328460069858
No
Department of Neonatology, Ali Asghar Hospital, Iran University of Medical Sciences, Tehran, Iran
Leila
Allahqoli
lallahqoli@gmail.com
200319475328460069859
200319475328460069859
No
Iran University of Medical Sciences, Tehran, Iran