en Urology and Nephrology Urology and Nephrology Original Research Original Research <strong>Background: </strong>The oncological outcomes of bladder cancer are directly associated with disease pathology and surgical technique. Therefore, we investigated the pathologic factors of radical cystectomy (RC) specimens.<br> &nbsp;&nbsp; <strong>Methods: </strong>In this retrospective study, 365 patients who underwent RC between March 2013 to March 2018 in hospitals affiliated to Shiraz University were enrolled. The patients&rsquo; clinicopathological parameters, such as tumor type, tumor grade, carcinoma in situ, lymph node (LN) involvement, lymphovascular invasion (LVI), perineural invasion (PNI), and age, were recorded from their pathology reports. For comparison of variables, an independent t test was used.&nbsp; P < 0.05 was regarded as significant. The statistical software SPSS version 22 was used to examine the data.<br> &nbsp;&nbsp; <strong>Results: </strong>The participants&rsquo; mean age was 64.52 &plusmn; 11.54 years, and 320 (87.7%) patients were men and 45 (12.3%) were women. The mean dissected LN was 9.69 &plusmn; 8.70 nodes and 1.06 &plusmn;3.49 of the dissected LNs were involved by tumor. PNI and perivesical invasion were presented in 148 (40.5%) and 96 (26.3%) patients, respectively. Ureteral, urethral, and prostate involvements were seen in 23 (6.3%), 50 (13.7%), and 66 (18.1%) patients. Most patients had pathologic tumor stage 2 (36.4%). Factors such as LVI, PNI, perivesical invasion, and prostate involvement, were strongly correlated with positive LN (P &le; 0.05).<br> &nbsp;&nbsp; <strong>Conclusion: </strong>The examination of the RC specimen is critical for patient care, outcome, and justification of adjuvant therapy.&nbsp; Factors such as LVI, perineural invasion, perivesical invasion, and prostate involvement were strongly correlated with positive LN.<br> &nbsp;<br> <strong><span dir="LTR"></span></strong> Bladder Cancer, Radical Cystectomy, Pathology, Lymph Node 1202 1206 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6066-1&slc_lang=en&sid=1 Ali Ariafar علی اریافر ariafara@sums.ac.ir 200319475328460066834 200319475328460066834 Yes Department of Urology, School of Medicine, & Urology Oncology Research Center, Shiraz University of Medical Since, Shiraz, Iran Shahryar Zeighami zeyghamishahryar@yahoo.com 200319475328460066835 200319475328460066835 No Department of Urology, School of Medicine, Shiraz University of Medical Since, Shiraz, Iran Mehdi Salehipour salehipourmehdi@yahoo.com 200319475328460066836 200319475328460066836 No Department of Urology, School of Medicine, Shiraz University of Medical Since, Shiraz, Iran Faisal Ahmed fmaaa2006@yahoo.com 200319475328460066837 200319475328460066837 No Urology Research Center, Al-Thora General Hospital, Department of Urology, School of Medicine, Ibb University of Medical Science, Ibb, Yemen Sara Saeedi Sara.saeidi1993@yahoo.com 200319475328460066838 200319475328460066838 No Department of Urology, School of Medicine, Shiraz University of Medical Since, Shiraz, Iran Hossein-Ali Nikbakht Ep.nikbakht@gmail.com 200319475328460066839 200319475328460066839 No 4. Social Determinants of Health Research Center, Health Research Institute, Department of Biostatistics and Epidemiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran