Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1399
10
1
gregorian
2021
1
1
35
1
online
1
fulltext
en
The Comparison of Antimicrobial Effect of Nigella sativa Nanoparticle and Chlorhexidine Emulsion on the Most Common Dental Cariogenicic Bacteria
Original Research
Original Research
<strong>Background: </strong>Tooth decay and periodontal disease are the most common chronic human and oral diseases, respectively, and bacterial plaque has a major role in their occurrence. Because of the importance of plaque control, this study was done to compare the antimicrobial effects of Nigella sativa nanoparticles and chlorhexidine emulsion on the most common dental cariogenicic bacteria.<br>
<strong> Methods:</strong> In this experimental study, the effects of 0.2% chlorhexidine mouthwash and Nigella sativa nanoparticle with different dilutions on Streptococcus mutans, Streptococcus sobrinus, Streptococcus salivarius, Lactobacillus acidophilus, Minococcal fecalis, and Enterococcus fecalis were compared using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assessment. Data were analyzed by SPSS Version 16.0 software, and statistical tests, including an independent sample t test.<br>
<strong>Results:</strong> Mean diameters of growth inhibition zone because of the nanoemulsion of Nigella sativa nanoparticle was close to each other in different bacteria (p=0.665). In addition, there was no significant difference between these values because of different dilutions of nanoemulsion even in different microbial species (p=0.778). The MIC and lethal concentrations of Nigella sativa nanoemulsion were similar for Enterococcus faecalis and Streptococcus mutans, and it was higher than other bacteria. In comparison, the MIC and MBC values of all bacteria in chlorhexidine were lower than those of the nanoemulsion.<br>
<strong>Conclusion:</strong> MIC and MBC values showed that Nigella sativa nanoemulsion affects tooth cariogenicic bacteria. Enterococcus faecalis and Lactobacillus acidophilus were the most resistant and susceptible bacteria to this nanoparticle, respectively, while the antimicrobial effects of Nigella sativa nanoemulsion were weaker than the chlorhexidine mouthwash.<span dir="RTL"></span><span dir="RTL"></span>
Nigella sativa, Nanoemulsion, Chlorhexidine, Dental Caries, Bacteria, Antimicrobial
1113
1119
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-5079-3&slc_lang=en&sid=1
Bahareh
Nazemi Salman
Dr.b.nazemi@gmail.com
200319475328460066116
200319475328460066116
No
Department of Pediatric Dentistry, School of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran
Shilan
Sallah
drshilansalah@yahoo.com
200319475328460066117
200319475328460066117
No
Department of Oral Medicine, School of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran
Fatemeh
Abdi
azam.m.abdi2016@gmail.com
200319475328460066118
200319475328460066118
No
Zanjan University of Medical Sciences, Zanjan, Iran
Sarvenaz
Salahi
salahi13639@gmail.com
200319475328460066119
200319475328460066119
No
Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran
Kobra
Rostamizadeh
rostamizadeh@zums.ac.ir
200319475328460066120
200319475328460066120
No
Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
Samira
Basir Shabestari
shabestari.s@iums.ac.ir
200319475328460066121
200319475328460066121
Yes
Department of Oral Medicine, School of Dentistry, Firoozgar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran