en Internal Medicine Internal Medicine Original Research Original Research <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><b><span style="font-size:9.0pt"><span style="font-style:normal">Background: </span></span></b><span style="font-size:9.0pt"><span style="font-style:normal">According to recent evidence, there is an association between some genetic factors and rheumatoid arthritis (RA). The aim of this study was to determine whether genetic variations in the interleukin 10 (IL10) and anti-cyclic citrullinated peptide (Anti-CCP) antibody loci were linked to RA.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Methods: </b>In this hospital-based case-control study with 224 cases and 194 healthy individuals, we investigated the association of IL-10 genotypes and anti-CCP antibodies with RA. Independent sample t, chi-square, and Fisher exact tests were used to assess the association between study variables. </span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Results:</b> Frequency of IL-10 -1082 A/G genotype in RA patients is significantly higher than the control group (odds ratio [OR], 1.67 [95% CI, 1.11-2.51]) (</span></span><span style="font-size:9.0pt">p</span><span style="font-size:9.0pt"><span style="font-style:normal">=0.009), while the frequency of IL-10-1082 A/A and G/G polymorphisms in RA patients was lower than controls and this finding for G/G polymorphism was statistically significant (</span></span><span style="font-size:9.0pt">p</span><span style="font-size:9.0pt"><span style="font-style:normal">=0.01). No significant difference was observed between the 2 studied groups regarding IL-10-592 C/C, C/A, and A/A polymorphisms (</span></span><span style="font-size:9.0pt">p</span><span style="font-size:9.0pt"><span style="font-style:normal">>0.05). The chance of RA occurrence among persons with positive anti-CCP was significantly (63.3 times [22.7-176.5]) higher than individuals with negative anti-CCP (</span></span><span style="font-size:9.0pt">p</span><span style="font-size:9.0pt"><span style="font-style:normal"><0.001).</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Conclusion:</b> According to our data, the chance of anti-CCP positivity in persons who have IL-10 genotype 1082 A/G is higher. Further studies are recommended to determine the relationship between IL-10 genotype 1082 G/A and RA. If such a relationship is proven, this finding as a diagnostic clue can help rheumatologists in the early detection of RA.</span></span></span></span></span></span></span></span><br> &nbsp; Interleukin‐10, Anti-Cyclic Citrullinated Peptide Antibodies, Rheumatoid Arthritis 715 719 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-7004-1&slc_lang=en&sid=1 Nasrin Moghimi nasrinmoghimi@muk.ac.ir 200319475328460072191 200319475328460072191 No Rheumatology Department, Kurdistan University of Medical Sciences, Sanandaj, Iran Abdorrahim Afkhamzadeh afkhama@gmail.com 200319475328460072192 200319475328460072192 No Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran Khaled Rahmani khaledrahmani111@muk.ac.ir 200319475328460072193 200319475328460072193 Yes Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran Nasrollah Shakiba saral_2004senah@yahoo.com 200319475328460072194 200319475328460072194 No Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran