Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1380
11
1
gregorian
2002
2
1
15
4
online
1
fulltext
en
FORMALIN AS A PERIPHERAL NOXIOUS STIMULUS CAUSES A BIPHASIC RESPONSE IN NUCLEUS PARAGIGANTOCELLULARIS NEURONS
Physiology
Physiology
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
The effects of formalin as a peripheral noxious stimulus on the activity of
lateral paragigantocellularis nucleus (LPGi) neurons were examined. Spontaneous
activity ofLPGi neurons was recorded after confirmation of their responsiveness
to acute pain, and thereafter formalin (50 µL, 2.5%) was injected in the
contralateral hindpaw. The response of the LPGi neurons was monitored for 60
min. A biphasic response with a peak lasting 3 to 5 min post-injection, and a
second more prolonged tonic excitatory response were obtained which corresponds
to the nature and time course of behavioral studies. It is concluded that LPGi
neurons may be involved in the processing of nociceptive information related to
formalin as a noxious stimulus.
Nucleus paragigantocellularis, Formalin test, Multiple unit recording, Rat.
231
236
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-243&slc_lang=en&sid=1
E
SOLEIMAN-NEJAD
20031947532846006814
20031947532846006814
No
From the Dept. of Physiology. Faculty of Medicine. Army University of Medical Sciences. Po. Box: 14185- 611. Tehran
Y
FATHOLLAHI
20031947532846006815
20031947532846006815
No
The Dept. of Physiology. School a/Medical Sciences. Tarbiat Modarres University. Po. Box: 14115-111. Tehran.
S
SEMNANIAN
20031947532846006816
20031947532846006816
Yes
the Institute of Biochemistry and Biophysics. Tehran University. Po.Box: 13145-1384. Tehran.l.R. Iran.