Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1380
8
1
gregorian
2001
11
1
15
3
online
1
fulltext
en
ALLERGIC FUNGAL SINUSITIS AMONG CANDIDATES FOR FUNCTIONAL ENDOSCOPIC SINUS SURGERY (FESS) IN SARI (IRAN)
Parasitology and Mycology
Parasitology and Mycology
Original Research
Original Research
Allergic fungal sinusitis (AFS) has been clinicopathologically defined as a
noninvasive form of fungal infection. This study was designed to distinguish AFS
among patients with chronic sinusitis who failed to respond to repeated courses
of antibiotics and were therefore candidates for functional endoscopic sinus surgery
(FESS) in Sari.
Allergic mucin and sinus lavage was collected during FESS from 100 patients
meeting the diagnostic criteria for AFS and were submitted for mycology
and pathology investigations. The specimens were centrifuged and the sediment
was mounted in 10% KOH and Gram's stain for direct examination. The specimens
were inoculated in Sabouraud's Dextrose Agar. Multiple fragments of mucosa
were removed at surgery and stained with H&E and PAS for the pathology
evaluation.
In this study we report 9 proven cases of AFS (with demonstration of fungal
hyphae by direct exam and culture) and 8 suspected cases (confirmed by direct
exam or culture). The patient's age ranged from 12 to 62 years, with a mean age of
24.5 years with female predominance. All of the patients were immunocompetent.
47% of the patients had a history of atopy. Histopathologically, hyphae were
not seen. The genera of the fungi were identifiable in all but one patient. 53% of
isolated fungi were from the hyaline hyphomycete group particularly Aspergillus
and Penicillium and 47% of them were members of the dematiaceous family particularly
Cladosporium and Nigrospora. In eleven out of the seventeen, fungal
hyphae were noted and in all of the seventeen there were positive fungal cultures.
Fungal sinusitis should be considered in all patients with chronic sinusitis
that fails to repond to repeated courses of treatment. Recent advances in endoscopy
and computed tomography and physician awareness will lead to improved
diagnosis and treatment and will prevent multiple surgical procedures
Sinusitis. Fungal, allergic, allergic mucin.
133
138
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-249&slc_lang=en&sid=1
T
SHOKOHI
20031947532846004139
20031947532846004139
Yes
From the Departments of Medical Mycology and Parasitology and *Olorhinolaryngology. A;fazandaran University of Medical Sciences. Sari. Islalllic Republic of Iran.
A
MADANI
20031947532846004140
20031947532846004140
No