en Biostatistics and Epidemiology Biostatistics and Epidemiology Original Research Original Research <strong>Background<strong>:</strong></strong>&nbsp;Depression is a prevalent illness in the world. Given the importance of mental disorders, many researchers have investigated the effects of different variables on average depression scores. In this study, we decided to investigate the effect of some explanatory variables on the average depression score.<br> <strong>Methods:&nbsp;</strong>The data were obtained from the second phase of the cohort of the Kerman Coronary Artery Diseases Risk Factors study (KERCADRS), which was performed in 2014-2018. We used the cluster-wise linear regression model to find more accurate relationships between depression scores and predictor variables.&nbsp;<br> <strong>Results:&nbsp;</strong>The total number of the subjects in this study was 9811, out of whom 2144 were allocated to cluster 1, 4540 to cluster 2, and 3127 to cluster 3. The average depression score was 13.76 <img alt="" height="28" src="file:////Users/zahrazamani/Library/Group%20Containers/UBF8T346G9.Office/TemporaryItems/msohtmlclip/clip_image002.png" width="12" >7.6 in cluster 1, 4.39 <img alt="" height="28" src="file:////Users/zahrazamani/Library/Group%20Containers/UBF8T346G9.Office/TemporaryItems/msohtmlclip/clip_image004.png" width="9" >&nbsp;4.7 in cluster 2, and 10.83 <img alt="" height="28" src="file:////Users/zahrazamani/Library/Group%20Containers/UBF8T346G9.Office/TemporaryItems/msohtmlclip/clip_image004.png" width="9" >&nbsp;6.7 in cluster 3. However, the average depression score for all the data was 8.5 <img alt="" height="28" src="file:////Users/zahrazamani/Library/Group%20Containers/UBF8T346G9.Office/TemporaryItems/msohtmlclip/clip_image004.png" width="9" >&nbsp;7.2. In all the clusters, the average depression score of females was significantly greater than that of men (p-value<0.0001). In cluster 1, the age category of 35-54, in cluster 2, the age category of 55-80, and in cluster 3, the age category of 15-34 had a maximum average depression score.<br> <strong>Discussion:</strong>&nbsp; we can name the three clusters to low ( cluster 2), medium ( cluster 3 ), and high (cluster 1) depression score with respect to age group with the maximum ADS in each cluster. that they are 55-80 years old, 15-34 years old and 35-54 years old in cluster 2 ( low), cluster 3 ( medium) and cluster 1( high) respectively. Depression, Coronary Artery Diseases, Clustering 881 889 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-3282-1&slc_lang=en&sid=1 Zahra Zamaninasab z.zamaninasab@gmail.com 200319475328460072835 200319475328460072835 No Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Hamid Najafipour najafipourh@yahoo.co.uk 200319475328460072836 200319475328460072836 No Department of Physiology and Pharmacology, School of Medicine, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran Moghaddameh Mirzaee M_mirzaee@kmu.ac.ir 200319475328460072837 200319475328460072837 Yes Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Abbas Bahrampour abahrampour@yahoo.com 200319475328460072838 200319475328460072838 No Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran