Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1400
10
1
gregorian
2022
1
1
36
1
online
1
fulltext
en
Evaluation of the Efficacy and Complications of Uterine Artery Embolization in Comparison with Laparotomy-Myomectomy in the Treatment of Uterine Myomas: A Randomized Clinical Trial
Gynecology & Obstetrics
Gynecology & Obstetrics
Original Research
Original Research
<span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><b><span style="font-size:9.0pt"><span style="font-style:normal">Background: </span></span></b><span style="font-size:9.0pt"><span style="font-style:normal">Due to the high prevalence of uterine fibroids or leiomyomas in women of reproductive age and the many treatment options for myomas, finding the best treatment is a challenge for surgeons. Therefore, this study aimed at evaluating the efficacy and safety of 2 treatment options surgical interventions and uterine artery embolization (UAE) in patients with uterine myoma.</span></span></span></span></span></span></span></span><br>
<span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal"> <b>Methods:</b> The present study was a single-blind randomized clinical trial. The study population included all women with uterine myoma. Hence, 80 patients were divided into 2 groups of 40. The first group underwent laparotomy-myomectomy and the second underwent UAE. These patients were evaluated for clinical symptoms, menstrual disorders, estimated blood loss per menstrual cycle, and pain and complication on the 10th day, and at 2, 6, and 12 months after the intervention. The data were analyzed with SPSS software (Version 25) using an independent samples t test, a repeated measure analysis, and a chi-square test. </span></span></span></span></span></span></span></span><br>
<span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal"> <b>Results:</b> Ten days, 2, 6, and 12 months after the intervention, there was no significant difference between the 2 approaches in terms of their decreasing effects on per menstrual cycle blood loss (</span></span><span style="font-size:9.0pt">p</span><span style="font-size:9.0pt"><span style="font-style:normal"> > 0.05), respectively. After 10 days and 2 months, the pain intensity in the embolization group was higher than laparotomy group (</span></span><span style="font-size:9.0pt">p </span><span style="font-size:9.0pt"><span style="font-style:normal">= 0.045, 0.060), respectively. The pain intensity was also not significantly different between the 2 groups after 6 months and 1 year (</span></span><span style="font-size:9.0pt">p</span><span style="font-size:9.0pt"><span style="font-style:normal"> > 0.05), respectively. Also, the frequency of fever was higher in the embolization group (</span></span><span style="font-size:9.0pt">p</span><span style="font-size:9.0pt"><span style="font-style:normal"> = 0.745). However, the documented post-procedural complications indicated that hemoglobin level declined post-operation (</span></span><span style="font-size:9.0pt">p</span><span style="font-size:9.0pt"><span style="font-style:normal"> > 0.050). </span></span></span></span></span></span></span></span><br>
<span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal"> <b>Conclusion:</b> The results showed no significant difference between the 2 groups in terms of post-procedural mensuration blood loss or pain intensity and the incidence of menstrual disorders within 1 year. It seems that there is no significant difference between the 2 groups and it may be possible to use the UAE depending on the patient's condition.</span></span></span></span></span></span></span></span>
Uterine Artery Embolization, Laparotomy, Myomectomy, Uterine Leiomyoma, Individualized Medicine
665
671
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-7365-1&slc_lang=en&sid=1
Zahra
Allameh
z_allameh@med.mui.ac.ir
200319475328460072020
200319475328460072020
No
Department Obstetrics and Gynecology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Soheila
Afzali
soheila.afzali2020@gmail.com
200319475328460072021
200319475328460072021
No
Department Obstetrics and Gynecology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Mohamadsaleh
Jafarpisheh
jafarpisheh@gmail.com
200319475328460072022
200319475328460072022
No
Department Radiology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Minoo
Movahedi
minoomovahedi@med.mui.ac.ir
200319475328460072023
200319475328460072023
No
Department Obstetrics and Gynecology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Leila
Mousavi Seresht
mousavi.lm@med.mui.ac.ir
200319475328460072024
200319475328460072024
Yes
Department Obstetrics and Gynecology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran