Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1400
10
1
gregorian
2022
1
1
36
1
online
1
fulltext
en
Bell's Palsy and COVID-19 Vaccination: A Systematic Review
Infectious Disease
Infectious Disease
Systematic Review
<span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><span style="font-style:italic"><b><span style="font-size:9.0pt"><span style="font-style:normal">Background: </span></span></b><span style="font-size:9.0pt"><span style="font-style:normal">Bell's palsy is a rare adverse event reported in COVID-19 vaccines. Given the importance of neurological manifestations, the necessity to highlight and scrutinize the incidence of them following COVID-19 vaccination is needed. This study aimed to systematically review the reported cases of Bell's palsy following vaccination against COVID-19.</span></span></span></span></span></span></span></span><br>
<span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal"> <b>Methods:</b> This systematic review is conducted based on the Cochrane Collaboration Handbook and PRISMA Statement (Preferred Reporting Items for Systematic Reviews and Meta-Analyzes) and using the Joanna Briggs Institute (JBI) methodology for systematic reviews. The inclusion criteria for the included published studies were patient age ≥18 years, history of Bell's palsy after COVID-19 vaccination and established diagnosis in the patients with COVID-19 vaccination. The exclusion criteria were repeated cases and missing clinical information. The search strategy aimed to find both published and unpublished studies in August 2021 and updated by hand searching in May 2022 using the identified keywords and index terms in Cochrane Library, MEDLINE (PubMed), Web of Science, Scopus, ProQuest, and Google scholar. Finally, the reference lists of all identified reports and articles were searched for additional studies. The JBI critical appraisal tools for case reports or case series were used to assess the risk of bias in the included studies.</span></span></span></span></span></span></span></span><br>
<span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal"> <b>Results: </b>During the electronic search, hand search, and reference check, we identified 1281 citations, and in hand searching, we detected additional 15 studies. After omitting duplicated citations and assessing the title, abstract, and full text 15 case-report and two case-series studies were included for the critical appraisal process and were included in this study. Pfizer and Moderna vaccines were the most common vaccines among articles that reported the cases of Bell’s palsy. Left-sided paralysis was more common than right-sided paralysis. The interval between receiving the vaccine and the onset of facial weakness was between 1 and 48 days. </span></span></span></span></span></span></span></span><br>
<span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal"> <b>Conclusion:</b> Further studies with larger sample sizes are necessary to assess the association between Bell's palsy and the dose-response of the COVID-19 vaccine.</span></span></span></span></span></span></span></span><br>
Bell's Palsy, COVID-19 Vaccination, Systematic Review
646
652
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-4650-2&slc_lang=en&sid=1
Kavous
Shahsavarinia
Kavous.Shahsavari@yahoo.com
200319475328460072010
200319475328460072010
No
Emergency and trauma care research center, & Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Ata
Mahmoodpoor
amahmoodpoor@yahoo.com
200319475328460072011
200319475328460072011
No
Department of Anesthesiology, Tabriz University of Medical Sciences, Tabriz, Iran
Fatemeh
Sadeghi-Ghyassi
ghyassif@tbzmed.ac.ir
200319475328460072012
200319475328460072012
No
Faculty of Management & Medical Informatics Tabriz University of Medical Science, Tabriz, Iran
Arezou
Nedayi
arezounedayi@gmail.com
200319475328460072013
200319475328460072013
No
Emergency and trauma care research center, Tabriz University of Medical Sciences, Tabriz, Iran
Alireza
Razzaghi
Razzaghi.alireza1@gmail.com
200319475328460072014
200319475328460072014
No
Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Mahsa
Zehi Saadat
Mahsasaadat88@gmail.com
200319475328460072015
200319475328460072015
Yes
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Hanieh
Salehi-Pourmehr
salehiha@tbzmed.ac.ir
200319475328460072016
200319475328460072016
No
Research center for Evidence-Based Medicine, Iranian EBM Center: A Joanna Briggs Institute Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran