Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1400
10
1
gregorian
2022
1
1
36
1
online
1
fulltext
en
The Role of Salivary C-Reactive Protein in Systemic and Oral Disorders: A Systematic Review
General
General
Review Article
Review Article
<span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><span style="font-style:italic"><b><span style="font-size:9.0pt"><span style="font-style:normal">Background: </span></span></b><span style="font-size:9.0pt"><span style="font-style:normal">Blood sampling is expensive, time-consuming, invasive, and requires technical facilities, which can be replaced by more convenient samples such as saliva. C-reactive protein (CRP) is a widely used biomarker in the management of many disorders and plasma CRP (pCRP) is suggested to be replaced by salivary CRP (sCRP). This study aimed to systematically review all available literature on the sCRP levels in systemic and oral disorders and how sCRP and pCRP levels correlate among these patients and healthy individuals. </span></span></span></span></span></span></span></span><br>
<span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal"> <b>Methods:</b> In this systematic review, a PubMed, Embase, Scopus, and Google Scholar search was conducted on October-2021 to identify all research investigating sCRP levels in systemic and oral disorders. </span></span></span></span></span></span></span></span><br>
<span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal"> <b>Results:</b> A total of 130 publications were analyzed in the review. Most of the studies reported that sCRP and pCRP levels are correlated, and sCRP is a reliable alternative for pCRP level for the diagnosis and management of medical conditions. sCRP has been measured in many different medical and oral disorders and significantly correlated with disease activity in most cases.</span></span></span></span></span></span></span></span><br>
<span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><span style="font-style:italic"><b><span style="font-size:9.0pt"><span style="font-style:normal"> Conclusion:</span></span></b><span style="font-size:9.0pt"><span style="font-style:normal"> Salivary CRP is a good alternative for Plasma CRP levels in most cases. </span></span></span></span></span></span></span></span><br>
C-reactive protein, Oral disorders, Saliva, Systemic disorders
1044
1059
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-7486-1&slc_lang=en&sid=1
Mahsa
Babaei
mahbabaei95@gmail.com
200319475328460074161
200319475328460074161
No
Shahid Beheshti University of Medical Sciences, Tehran, Iran
Saeid
Rezaei
saeidiums@gmail.com
200319475328460074162
200319475328460074162
No
Iran University of Medical Sciences, Tehran, Iran
Shadi
Saghafi Khadem
saghafiS@mums.ac.ir
200319475328460074163
200319475328460074163
No
Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
Iman
Shirinbak
iman.shirinbak@gmail.com
200319475328460074164
200319475328460074164
No
Oral and Maxillofacial Surgery, Alborz University of Medical Sciences, Karaj, Iran
Samira
Basir Shabestari
shabestari.s@iums.ac.ir
200319475328460074165
200319475328460074165
Yes
Department of Oral Medicine, School of Dentistry, Firoozgar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran