en Gynecology & Obstetrics Gynecology & Obstetrics Original Research Original Research <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><b><span style="font-size:9.0pt"><span style="font-style:normal">Background: </span></span></b><span style="font-size:9.0pt"><span style="font-style:normal">This study aimed to compare sublingual misoprostol alone or combined with vaginal Isoniazid (INH) for first-trimester abortion.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Methods: </b>In this randomized controlled trial, 80 pregnant women with missed abortion candidates for first-trimester abortion were randomly assigned to two groups. The first group received 800 &mu;g sublingual misoprostol every three hours maximum for three doses and the second group received 1500 mg vaginal INH followed by the same dose of misoprostol. Vaginal sonography was performed after 24 hours on both groups to observe any retained product of conception. In case of no response or incomplete abortion, the&nbsp; second course of misoprostol (with the same dose) was administered. The abortion (complete or incomplete) rate was reported within 48 hours after the first dose of misoprostol.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Results:</b> The rate of successful intervention (either complete or incomplete) abortion within 48 hours of misoprostol administration was 75% in both groups and was not significantly different (</span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal"> value = 1). Also, hospitalization duration, abortion time, total misoprostol dosage, and the rate of side effects were similar in the two groups. Five patients in the misoprostol group and three in the misoprostol plus isoniazid group underwent emergent D&C because of heavy bleeding. </span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Conclusion: </b>A combined regimen of sublingual Misoprostol plus vaginal Isoniazid with the prescribed dosage has similar efficacy to sublingual misoprostol alone in first-trimester abortion.</span></span></span></span></span></span></span></span><br> &nbsp; Abortion, First-trimester, Misoprostol, Isoniazid 82 87 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-7535-1&slc_lang=en&sid=1 Ladan Haghighi dr.ladanhaghighi@yahoo.com 200319475328460076217 200319475328460076217 No Endometriosis Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran Maryam Rahimi rahimi.m@iums.ac.ir 200319475328460076218 200319475328460076218 No Department of Obstetrics and Gynecology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Behnaz Mohabatian dr.mohabatian@gmail.com 200319475328460076219 200319475328460076219 No Department of Obstetrics and Gynecology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Zahra Rampisheh rampisheh@gmail.com 200319475328460076220 200319475328460076220 No Department of Obstetrics and Gynecology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Mahshid Shirvani shirvani.mahshid777@gmail.com 200319475328460076221 200319475328460076221 Yes Department of Obstetrics and Gynecology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Samaneh Saghafian Larijani saghafian.s@iums.ac.ir 200319475328460076222 200319475328460076222 No Department of Obstetrics and Gynecology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran