Medical Journal of the Islamic Republic Of Iran

en Prognostic Factors of Disease Recurrence and Overall Survival Following Curative Resection of Colon Cancer: A 10-year Cohort from a Referral Center Surgery Surgery Original Research Original Research     Background: The growing incidence of colorectal cancer around the world highlights the significance of tumor recurrence and patient survival as 2 key elements of patient therapy. We aimed to study the factors linked with disease recurrence and survival in colon cancer.    Methods: Patients with colon cancer who underwent tumor excision as their primary treatment were enrolled in this prospective cohort and monitored for 10 years. Various demographic and clinicopathologic factors of these patients were studied in association with the 2 primary outcomes of this study, including tumor recurrence and patient survival. Statistical tests and survival analysis were utilized to explore the study aims.    Results: An overall number of 113 patients were included in this survey with a mean age of 54.7 (±SD, 14.1), and most of the patients were men (56.6%). The mean follow-up period was 28.3 (±25.5) months. Tumor recurrence occurred in 32 (28.3%) patients in the study period. The estimated mean survival of patients was 54.9 (95% CI, 45.3-64.4) months. N staging (p= 0.036), T staging (p= 0.009), and pathologic staging (P = .004) were the significant pathological factors to higher tumor recurrence and lower survival rates.    Conclusion: Advanced tumor staging led to increased disease recurrence and lower survival of colon cancer patients in this survey. Further public health screening and education programs are needed to improve the early detection and prognosis of these patients in Iran.   Colon Cancer, Survival Analyses, Recurrence, Surgery 1060 1065 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-339-6&slc_lang=en&sid=1 Mohammad Reza Keramati mr-keramati@tums.ac.ir 200319475328460074151 200319475328460074151 Yes Division of Colorectal Surgery, Department of Surgery, & Colorectal Research Center, Tehran University of Medical Sciences, Tehran, Iran Sina Delazar sinade2005@gmail.com 200319475328460074152 200319475328460074152 No Colorectal Research Center, & Department of Radiology, Tehran University of Medical Sciences, Tehran, Iran Mohammad Reza Tabari mohammadrezatabary@gmail.com 200319475328460074153 200319475328460074153 No Colorectal Research Center, Tehran University of Medical Sciences, Tehran, Iran Farnaz Araghi farnaz_1101@yahoo.com 200319475328460074154 200319475328460074154 No Colorectal Research Center, Tehran University of Medical Sciences, Tehran, Iran Sina Azadnajafabad sina.azad.u@gmail.com 200319475328460074155 200319475328460074155 No Division of Colorectal Surgery, Department of Surgery, & Colorectal Research Center, Tehran University of Medical Sciences, Tehran, Iran Alireza Kazemeini alikazemeini@gmail.com 200319475328460074156 200319475328460074156 No Division of Colorectal Surgery, Department of Surgery, & Colorectal Research Center, Tehran University of Medical Sciences, Tehran, Iran Seyed Mohsen Ahmadi-Tafti smohsenahmadi1364@gmail.com 200319475328460074157 200319475328460074157 No Division of Colorectal Surgery, Department of Surgery, & Colorectal Research Center, Tehran University of Medical Sciences, Tehran, Iran Behnam Behboudi dr.b.behboudi@gmail.com 200319475328460074158 200319475328460074158 No Division of Colorectal Surgery, Department of Surgery, & Colorectal Research Center, Tehran University of Medical Sciences, Tehran, Iran Amir Keshvari keshvari@tums.ac.ir 200319475328460074159 200319475328460074159 No Division of Colorectal Surgery, Department of Surgery, & Colorectal Research Center, Tehran University of Medical Sciences, Tehran, Iran Mohammad Sadegh Fazeli mhfazeli@sina.tums.ac.ir 200319475328460074160 200319475328460074160 No Division of Colorectal Surgery, Department of Surgery, & Colorectal Research Center, Tehran University of Medical Sciences, Tehran, Iran