Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1400
10
1
gregorian
2022
1
1
36
1
online
1
fulltext
en
Asthma and COPD Overlap Syndrome (ACOS): Risk Factors and Contributing Factors
Pulmonary Disease
Pulmonary Disease
Original Research
Original Research
<span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><span style="font-style:italic"><b><span style="font-size:9.0pt"><span style="font-style:normal">Background: </span></span></b><span style="font-size:9.0pt"><span style="font-style:normal">The exact description of asthma and chronic obstructive pulmonary disease overlap syndrome (ACOS) is uncertain. This study aims to determine the frequency and symptoms of ACOS and to verify certain risk factors associated with ACOS.</span></span></span></span></span></span></span></span><br>
<span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal"> <b>Methods:</b> Severe asthmatic patients with and without ACOS above 40 years old participated in this cross-sectional study. The receiver operating curve analysis (ROC) was used to assess the best cutoff values of age, body mass index (BMI), and spirometric data to distinguish asthma patients with overlap syndrome from asthma patients without overlap syndrome. Univariable and multivariable binary logistic regression was used to determine demographic and clinical factors that were associated with ACOS and asthma.</span></span></span></span></span></span></span></span><br>
<span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal"> <b>Results:</b> Of the 88 patients, 46 (52.2%) had ACOS and 42 (47.7%) had just severe asthma. The mean age of ACOS patients (Sd) was 54.91(12.57) years and in asthma-only patients was 48.69 (13.51). The ROC analysis for age and BMI showed that age </span></span><span style="font-size:9.0pt"><span style="font-family:"Cambria Math",serif"><span style="font-style:normal">⩾ </span></span></span><span style="font-size:9.0pt"><span style="font-style:normal">49 years and BMI </span></span><span style="font-size:9.0pt"><span style="font-family:"Cambria Math",serif"><span style="font-style:normal">⩾ </span></span></span><span style="font-size:9.0pt"><span style="font-style:normal">27 kg/m<sup>2</sup> were the best predictors of ACOS in this study. Spirometry data showed that the forced vital capacity (FVC) (lit) > 2.16, forced expiratory volume in the first second (FEV1) > 69, FEV1 / FVC > 96.5, and FVC (%) > 63 cut points could be used to determine the diagnostic criteria between ACOS and asthma only, respectively. Multivariate modeling showed that among the demographic and clinical variables, only age over 49 years (odds ratio [OR], 3.53 [95% CI, 1.07-11.63] </span></span><span style="font-size:9.0pt">p</span><span style="font-size:9.0pt"><span style="font-style:normal"> = 0.025) and living in a big city (OR, 7.42 [95% CI, 1.75-31.49] </span></span><span style="font-size:9.0pt">p</span><span style="font-size:9.0pt"><span style="font-style:normal"> = 0.007) were significant.</span></span></span></span></span></span></span></span><br>
<span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:"Times New Roman",serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal"> <b>Conclusion:</b> Age over 49 and BMI above 27 have a significant association with ACOS. Also, living in a big city is considered to be another risk factor for ACOS compared with asthma. Spirometry can help distinguish ACOS from severe asthma in this study.</span></span></span></span></span></span></span></span><br>
Asthma, Pulmonary Disease, Chronic Obstructive, Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome
1153
1159
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-7693-1&slc_lang=en&sid=1
Hossein
Esmaeilzadeh
esmailzadeh_ho@yahoo.com
200319475328460074822
200319475328460074822
No
Allergy Research Center, & Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Hesamedin
Nabavizadeh
drhesamnabavi@yahoo.com
200319475328460074823
200319475328460074823
No
Allergy Research Center, & Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad Amin
Gholami
stud2282467140@sums.ac.ir
200319475328460074824
200319475328460074824
Yes
Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad Reza
Yousefi
M.r.yousefi.1319@gmail.com
200319475328460074825
200319475328460074825
No
Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Negar
Mortazavi
mortazavi_ne@yahoo.com
200319475328460074826
200319475328460074826
No
Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Mohebat
Vali
mohebatvali@gmail.com
200319475328460074827
200319475328460074827
No
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran