en Pharmacology Pharmacology Original Research: Basic Science in Medicine Original Research: Basic Science in Medicine Teucrium polium L. (Lamiaceae) is used in the traditional medicine of Iran for the treatment of disorders of the gastrointestinal tract. The essential oil from the aerial parts of T polium was assessed for antispasmodic activity and compared with the effect of atropine and dicyclomine. Acetylcholine and KC I were used for induction of contraction on rat isolated ileum. Teucrium polium essential oil (TPEO) at concentrations of 8.6 to 34.4 µg/mL attenuated the maximum inducible response to acetylcholine concentration-response curve. It also inhibited the response to 80 mM KC I in a concentration dependent manner (pD2= 1.2±0 .13). Dicyclomine (3.46 & 34.6 ng/mL) also reduced the response to acetylcholine on rat isolated ileum and inhibited KC1-induced contractions while atropine only inhibited the response to acetylcholine. This study shows that TPEO is a relaxant of rat isolated ileum and may have some clinical benefits for gastrointestinal disorders such as colic. Teucrium polium L., Lamiaceae, Essential oil, Antispasmodic 355 358 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-291&slc_lang=en&sid=1 H SADRAEISADRAEI hsadraei@yahoo.com 20031947532846004286 20031947532846004286 Yes From the Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran. V HAJHASHEMI 20031947532846004287 20031947532846004287 No A GHANNADI 20031947532846004288 20031947532846004288 No M MOHSENI 20031947532846004289 20031947532846004289 No