en Endocrinology Endocrinology Original Research Original Research <div style="text-align: justify;"><span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><b><span style="font-size:9.0pt"><span style="font-style:normal">Background: </span></span></b><span style="font-size:9.0pt"><span style="font-style:normal">During the COVID-19 pandemic, patients with diabetes are among the most vulnerable. Our purpose is to research the dynamics of morbidity, mortality, and survival of patients with diabetes in Kazakhstan before and during the current pandemic.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><b><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; Methods: </span></span></b><span style="font-size:9.0pt"><span style="font-style:normal">The indicators were calculated taking into account gender and nosological forms (E10-E14, according to ICD-10).The survival analysis was performed by the method of constructing survival tables and the Kaplan-Meier method. Based on methods, the official reporting data of 1,903,243 cases of diabetes and 20,605 deaths from diabetes were analyzed for the period 2018-2021.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><b><span style="font-size:9.0pt"><span style="font-style:normal">Results: </span></span></b><span style="font-size:9.0pt"><span style="font-style:normal">In Kazakhstan, during the COVID-19 pandemic, there has been an increase in the absolute frequency of all cases of diseases by 1.8 times (716,048 in 2021 against 396,990 in 2018) and newly detected by 2.0 times (from 38,396 to 75,027), also prevalence by 1.7 times (3743.9 in 2021 against 2142.2 in 2018) and incidence E10-E14 by 1.9 times (392.3 in 2021 against 207.2 in 2018). Mortality from E10-E14 in Kazakhstan increased during the pandemic by more than 1.5 times (34.1 per 100,000 in 2021 against 22.3 per 100,000 in 2018), and the average survival time at E10-E14 shifted (from 69.8 to 70.5 years) (</span></span><span style="font-size:9.0pt">P </span><span style="font-size:9.0pt"><span style="font-style:normal">= 0.001).</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><b><span style="font-size:9.0pt"><span style="font-style:normal">Conclusion: </span></span></b><span style="font-size:9.0pt"><span style="font-style:normal">To a greater extent, the increase in diseases and terminal outcomes occurred due to non-insulin-dependent type (E11) diabetes, mainly in the female population.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal"></span></span></span></span></span></span></span></span><br> &nbsp;</div> COVID-19, Diabetes, E10-E14, Incidence, Prevalence, Mortality, Survival 275 281 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-7844-1&slc_lang=en&sid=1 Ainagul Beissova abeissova@yandex.ru 200319475328460076660 200319475328460076660 No al-Farabi Kazakh National University, Almaty, Kazakhstan Vitaly Kamkhen kamchen_23@mail.ru 200319475328460076661 200319475328460076661 No Department of Epidemiology, Biostatistics and Evidence-Based Medicine, al-Farabi Kazakh National University, Almaty, Kazakhstan Mira Turbekova meerakz@mail.ru 200319475328460076662 200319475328460076662 Yes Department of Clinical Disciplines, al-Farabi Kazakh National University, Almaty, Kazakhstan Maulen Malgazhdarov maulen-ms@mail.ru 200319475328460076663 200319475328460076663 No Department of Surgery with a Course of Anesthesiology and Resuscitation, Kazakhstan-Russian Medical University, Almaty, Kazakhstan Sabira Koshkimbayeva koshkimbayeva.s@gmail.com 200319475328460076664 200319475328460076664 No Department of Epidemiology, Biostatistics and Evidence-Based Medicine, al-Farabi Kazakh National University, Almaty, Kazakhstan Lyaila Kozhabek lailya_kojabek@mail.ru 200319475328460076665 200319475328460076665 No Department of Epidemiology, Biostatistics and Evidence-Based Medicine, al-Farabi Kazakh National University, Almaty, Kazakhstan