en Gynecology & Obstetrics Gynecology & Obstetrics Original Research Original Research Twenty patients with bulky (>4 cm size) FIGO stage IB cervical cancer were treated with cisplatin 50 mg/m2 and vincristine 1 mg/m2, administered intravenously at 10-day intervals for a total of 3 courses before radical hysterectomy. A complete clinical response was noted in 1 patient (5%) and partial response in 5 (25%). Fourteen patients (70%) had stable disease. There was no grade 3 toxicity noted. Of the 20 patients who received chemotherapy (ChT), 3 patients had parametrial and para-aortic involvement in these cases, the operation was aborted and radiation therapy given. The remaining 17 patients underwent radical hysterectomy and pelvic lymphadenectomy 10-15 days following ChT. Five of these patients (29.4%) had pelvic node metastases. Three patients had positive margins. These 8 patients received postoperative radiotherapy. Twenty-four months later 15 patients were alive (87%) and 2 had died. 241 243 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-314&slc_lang=en&sid=1 N BEHTASH 20031947532846006830 20031947532846006830 Yes From the Department of Gynecology-Oncology, Vali-E-Asr Hospital, Tehran University 0F Medical Sciences, Tehran, I.R. Iran. M MODARES 20031947532846006831 20031947532846006831 No F GHAEM-MAGHAMI 20031947532846006832 20031947532846006832 No A MOUSAVI 20031947532846006833 20031947532846006833 No K SALEHI 20031947532846006834 20031947532846006834 No