Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1379
8
1
gregorian
2000
11
1
14
3
online
1
fulltext
en
NEOADJUVANT CHEMOTHERAPY WITH VINCRISTINE AND CISPLATIN FOLLOWED BY RADICAL HYSTERECTOMY AND PELVIC LYMPH ADENECTOMY FOR FIGO STAGE IB BULKY CERVICAL CANCER
Gynecology & Obstetrics
Gynecology & Obstetrics
Original Research
Original Research
Twenty patients with bulky (>4 cm size) FIGO stage IB cervical cancer were
treated with cisplatin 50 mg/m2 and vincristine 1 mg/m2, administered intravenously
at 10-day intervals for a total of 3 courses before radical hysterectomy. A
complete clinical response was noted in 1 patient (5%) and partial response in 5
(25%). Fourteen patients (70%) had stable disease. There was no grade 3 toxicity
noted. Of the 20 patients who received chemotherapy (ChT), 3 patients had parametrial
and para-aortic involvement in these cases, the operation was aborted and
radiation therapy given. The remaining 17 patients underwent radical hysterectomy
and pelvic lymphadenectomy 10-15 days following ChT. Five of these patients
(29.4%) had pelvic node metastases. Three patients had positive margins.
These 8 patients received postoperative radiotherapy. Twenty-four months later
15 patients were alive (87%) and 2 had died.
241
243
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-314&slc_lang=en&sid=1
N
BEHTASH
20031947532846006830
20031947532846006830
Yes
From the Department of Gynecology-Oncology, Vali-E-Asr Hospital, Tehran University 0F Medical Sciences, Tehran, I.R. Iran.
M
MODARES
20031947532846006831
20031947532846006831
No
F
GHAEM-MAGHAMI
20031947532846006832
20031947532846006832
No
A
MOUSAVI
20031947532846006833
20031947532846006833
No
K
SALEHI
20031947532846006834
20031947532846006834
No