en Biological Sciences Biological Sciences Original Research Original Research Administration of apomorphine and amphetamine induces climbing behavior in mice due to stimulation of brain dopamine receptors. In the present study, the effects of adrenoceptor agonists and antagonists on amphetamine-induced climbing have been investigated. Intraperitoneal (i.p.) injection of different doses of amphetamine (2,4 and 8 mglkg) induced climbing in mice (p<O.OOO 1). The u2- adrenoceptor agonist clonidine decreased the climbing induced by amphetamine (p<0.01). The adrenoceptor antagonists prazosin, yohimbine and propranolol did not alter amphetamine response. It may be concluded that α1- and α2-adrenoceptor stimulation decreases amphetamine- induced climbing behavior indirectly through changing dopamine levels. Adrenergic agents, Amphetamine, Climbing, Mice. 283 287 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-319&slc_lang=en&sid=1 M SHAFIEZADEH 20031947532846004377 20031947532846004377 Yes From the Institute of Biochemistry & Biophysics, University of Tehran MR ZARRINDAST 20031947532846004378 20031947532846004378 No the Department of Pharmacology, Tehran University of Medical Sciences Y FATHOLLAHI 20031947532846004379 20031947532846004379 No the Department of Physiology, Tarbiat Modarres University. Tehran, I.R. Iran. S SEMNANIAN 20031947532846004380 20031947532846004380 No the Department of Physiology, Tarbiat Modarres University. Tehran, I.R. Iran.