en Biological Sciences Biological Sciences Original Research Original Research The involvement of elements in the pathological process of primary hypertension has been established. The serum levels of copper, iron, zinc, sodium, potassium and calcium were studied by atomic absorption spectrophotometery and flame photometry in hypertensive and normal subjects. Serum copper and zinc levels were increased in hypertensive patients (25.5% and 14.7% respectively) as compared to normal subjects. A decrease in serum sodium (21".9%), potassium (31.02%), iron (44.7%) and calcium (34.23%) was observed in hypertensive as compared to control subjects. The role of these serum element variations and their possible involvement in hypertension is discussed. 115 118 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-327&slc_lang=en&sid=1 M MOMTAZ 20031947532846004403 20031947532846004403 No N MUGHAL 20031947532846004404 20031947532846004404 No AZHAR SIDDIQUE 20031947532846004405 20031947532846004405 No TABASSUM MAHBOOB 20031947532846004406 20031947532846004406 Yes From the Departments of Chemistry and *Biochemistry, University of Karachi, Karachi 75270, Pakistan.