Medical Journal of the Islamic Republic Of Iran

en Survival Analysis of Risk Factors for Mortality of Patients with Cardiovascular Diseases at Tikur Anbessa Specialized Tertiary Referral Hospital, Ethiopia: A Retrospective Cardiovascular Cardiovascular Original Research Original Research     Background: Cardiovascular diseases (CVD) represent a leading cause of global mortality, necessitating proactive identification of risk factors for preventive strategies. This study aimed to uncover prognostic factors influencing cardiovascular patient survival.    Methods: This study, which used a sample size of 410, showed how to analyze data using simple random sampling. It was conducted at the Tikur Anbessa Specialist Hospital in Addis Ababa, Ethiopia, between September 2012 and April 2016. The Cox PH and stratified Cox regression models were used for the analysis.    Results: Findings disclosed a patient cohort where 200 patients (48.8%) persisted through subsequent evaluation, while 210 patients (51.2%) succumbed. Blood pressure (BP), specific CVD, and education levels (EL) exhibited nonproportionalities in scaled Schoenfeld residuals (P < 0.001), prompting necessary stratification. Inadequacies in the Cox proportional hazards model led to favoring the stratified Cox model. Notably, EL, BP, cholesterol level (CL), alcohol use (AU), smoking use (SU), and pulse rate (PR) exhibited statistical significance (P < 0.001). Acceptability of the absence of interaction in the model, with disease types as strata, was established. Different cardiovascular conditions served as distinct groups, where EL, AU, BP, PR, CL, and SU emerged as variables with statistically substantiated significance associated with the mortality of patients with CVD.    Conclusion: Implications stress the imperative of widespread awareness among policymakers and the public concerning cardiovascular disease incidence. Such awareness is pivotal in mitigating identified risk factors, guiding more effective healthcare interventions tailored to the multifaceted challenges posed by cardiovascular health.   Cardiovascular, Cox proportional hazard model, Cox-Snell residual, Noncommunicable disease, Stratified Cox regression model 124 130 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-8232-1&slc_lang=en&sid=1 Ashefet Agete pbdarab@yahoo.com 200319475328460088842 200319475328460088842 No Department of Statistics, Hawassa University, Ethiopia Girma Altaye mkhosravi243@yahoo.com 200319475328460088843 200319475328460088843 No Ebrahim Talebi Ebrahim.Talebi@iau.ac.ir 200319475328460088844 200319475328460088844 Yes Darab Branch, Islamic Azad University, Darab, Iran