en Infectious Disease Infectious Disease Systematic Review <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><b><span style="font-size:9.0pt"><span style="font-style:normal">Background: </span></span></b><span style="font-size:9.0pt"><span style="font-style:normal">Polymorphisms in the vitamin D receptor (VDR) play an effective role in the susceptibility of pulmonary tuberculosis (TB). Given the importance of this polymorphism and its association with pulmonary TB, this study aimed to investigate the prevalence of VDR polymorphisms in people with pulmonary TB.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Methods:</b> The search process was performed from 2009 to 2023 according to PRISMA (Preferred reporting items for systematic reviews and meta-analyses). The strengthening of the reporting of observational studies in epidemiology (STROBE) checklist was used to qualify the articles. The data was entered into STATA version 14 software, then the fixed effects model and the random effects model, effect size (ES), and Q test (</span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal"> < 0.10) were used for data analysis at a confidence interval level (CI) of 95%. Two-sided statistical tests were considered with &alpha;=0.05.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Results:</b> In this research, 28 articles were analyzed. Polymorphisms showed a significant relationship with susceptibility to pulmonary TB (</span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal"> = 0.000), and significant heterogeneity (</span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal"> = 0.000) was seen between polymorphisms. FokI (95% CI: 0.39-0.46, </span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal"> = 0.000, ES = 43%), ApaI (95% CI: 0.31-0.48, </span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal"> = 0.000, ES = 39%) and BsmI&nbsp; (95% CI: 0.24-0.50, </span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal"> = 0.000, ES = 37%) showed the most frequent gene polymorphisms after TaqI (95% CI: 0.34-0.77, </span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal"> = 0.000, ES = 56%).</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Conclusion:</b> ApaI, BsmI, FokI, and TaqI polymorphisms were found in patients suffering from pulmonary TB. Polymorphisms related to the TaqI gene were the most frequent. Controlling and prescribing vitamin D may be needed in these patients.</span></span></span></span></span></span></span></span><br> &nbsp; Vitamin D Receptor Genes, Polymorphisms, Pulmonary Tuberculosis. 210 221 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-2142-1&slc_lang=en&sid=1 Rasool Samimi researchcenter@qums.ac.ir 200319475328460088896 200319475328460088896 No Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran Afra Hossein Panahi sama_tanha0123@yahoo.com 200319475328460088897 200319475328460088897 No Lung Diseases and Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran Roja Zaboli roja.zaboli@yahoo.com 200319475328460088898 0007-0009-4002-2895 No Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran Amir Peymani hamaidmoqhtader@yahoo.com 200319475328460088899 200319475328460088899 No Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran Samaneh Rouhi s.rohi@qums.ac.ir 200319475328460088900 200319475328460088900 Yes Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran Somayeh Ahmadi Gooraji ahmadisomayeh90@gmail.com 200319475328460088901 200319475328460088901 No Department of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Neda Rajai n_rajai@yahoo.com 200319475328460088902 0009-0006-1871-0125 No Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran