Medical Journal of the Islamic Republic Of Iran

en Evaluation of Preventive Pentoxifylline Effect on Acute Respiratory Distress Syndrome (ARDS) Incidence in Traumatic Patients: A Randomized Triple-Blind Placebo-Controlled Trial Pulmonary Disease Pulmonary Disease Original Research Original Research Background: Inflammation is important in the pathophysiology of acute respiratory distress syndrome (ARDS). Traumatic injuries have been assumed to be primary ARDS causes. Recently, pentoxifylline, a phosphodiesterase inhibitor (PEI), was shown to have anti-inflammatory effects and reduce the incidence of ARDS. The present study investigated the impact of preventive pentoxifylline administration in trauma patients prone to ARDS development.    Methods: A total of 62 trauma patients admitted to the Kamyab Hospital in Mashhad,Iran, with ARDS risk who fulfilled the inclusion and exclusion criteria were included in this study. The patients were randomly divided into treatment and placebo groups. The treatment group received 400 mg pentoxifylline 3 times a day, while the control group received placebo tablets thrice for 1 week. Before the intervention and during the study, factors such as heart rate, blood pressure, respiration rate, continuous pulse oximetry, CRP, PO2, PCO2, and PH were assessed. Finally, the obtained data were analyzed using SPSS Version 26 via a generalized estimating equations model and an independent t test.    Results: The heart rate was significantly lower in the treatment group than in the placebo group (P = 0.036). In addition, PO2 levels were remarkably higher in the treatment group (P = 0.040). Changes in respiratory rate (P = 0.064), CRP (P = 0.341), PH (P = 0.910), PCO2 (P = 0.892), HCO3 (P = 0.172), systolic blood pressure (P = 0.302), and SPO2 (P = 0.350) were not significantly different between the 2 groups. In addition, no significant difference was observed in the incidence and severity of ARDS between the 2 groups.    Conclusion: The findings of this study revealed that pentoxifylline administration to trauma patients had no beneficial effects on ARDS but improved some vital signs and laboratory variations.              Acute Respiratory Distress Syndrome, Pentoxifylline 425 432 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-8392-1&slc_lang=en&sid=1 Sepehr Shirzadeh shirzadehs981@mums.ac.ir 200319475328460089327 200319475328460089327 No General Surgery Resident, Department of General Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Navid Omidkhoda OMIDKHODAN991@MUMS.AC.IR 200319475328460089328 200319475328460089328 No Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Amir Hooshang Mohammadpour mohamadpoorah@mums.ac.ir 200319475328460089329 200319475328460089329 No Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Reza Mannani MANNANIR@ZUMS.AC.IR 200319475328460089330 200319475328460089330 No Department of Surgery, Zanjan University of Medical Science, Zanjan, Iran Vahid Jomehzadeh jomehzadehV@mums.ac.ir 200319475328460089331 200319475328460089331 Yes Department of Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran