Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1379
2
1
gregorian
2000
5
1
14
1
online
1
fulltext
en
PREVENTIVE EFFECTS OF VITAMIN B12 AND FOLIC ACID IN METHANOL-INDUCED RETINOPATHY IN AN ANIM AL MODEL
Drug
Drug
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
In order to identify the effects of vitamin B 12 and folic acid in reducing methanolinduced
retinopathy, ERG waves were compared before and after methanol
intoxication in rabbits. In this study 34 rabbits were divided into 4 groups. All groups
received 4 g/kg of methanol intraperitoneally. In addition, the second, third and
fourth groups received vitamin B 12 injection, oral folic acid and a mixture of vitamin
B12 and folic acid, respectively.
Baseline ERGs were recorded for all rabbits prior to intoxication and then
second ERGs were taken 48-72 hours following methanol toxicity. Compared to
baseline ERGs a severe reduction in the b-wave amplitude as well as reduction in
the oscillatory potential were noticed. Among all groups, the first group had the most
and the fourth group had the least decrease in b-wave amplitude as well as oscillatory
potential. It is therefore believed that vitamin B12 has a synergistic effect with folic
acid in attenuating ophthalmic toxicity of methanol in rabbits. Further studies are
needed to evaluate these effects in humans.
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http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-360&slc_lang=en&sid=1
HA
SHAHRIARI
20031947532846004515
20031947532846004515
Yes
From Zahedan University of Medical Sciences, Dr. Shariati Ave, Zahedan, 98134, I.R . Iran.
A
HOSSEINI RAD
20031947532846004516
20031947532846004516
No