Medical Journal of the Islamic Republic Of Iran

en Determining Predictive Power of Base Excess in Comparison with SOFA Score for Predicting Mortality in ICU Patients Internal Medicine Internal Medicine Original Research Original Research Background: Acid-base disturbances are frequently found in intensive care unit (ICU) patients. Base excess (BE) is commonly used to quantify the degree of metabolic impairment. We aimed to compare the predictive value of BE and Sequential Organ Failure Assessment (SOFA) score for mortality in ICU patients.    Methods: This prospective and observational investigation was performed on 87 ICU patients who underwent mechanical ventilation. SOFA score and acid-base variables at 6 hours of ICU admission were analyzed and compared between survivors and non-survivors. Receiver-operating characteristic (ROC) curve was applied to analyze the predictive value of BE and SOFA for mortality.    Results: Mean age of patients was 63.91±5.03 years, and 60 (69%) were male. The non-survived patients had significantly higher SOFA (P = 0.001) and APACHE II scores (P = 0.001). The non-survived patients had a lower bicarbonate (P = 0.002), PO2 (P = 0.001), pH (P = 0.0021), and a higher PCO2 (P = 0.001) compared with survivors, and most patients who died (80%) had a low BE value (< -2) (P = 0.002). The estimated AUC of SOFA and BE was 0.83 (95% CI, 0.73 - 0.92) and 0.71 (95% CI, 0.57 – 0.85), respectively.    Conclusion: BE is, to some extent capable of predicting mortality in ICU patients. However, the SOFA score is a more accurate and reliable parameter in comparison to BE for prediction.        SOFA, Base Excess, Intensive Care, Mortality 508 511 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-3180-3&slc_lang=en&sid=1 Omid Moradi Moghaddam moghadam.o@iums.ir 200319475328460089379 200319475328460089379 No Trauma and Injury Research Center, Iran University of Medical Sciences, Tehran, Iran Mohammajavad Gorjizadeh gorjizadeh@iums.ac 200319475328460089380 200319475328460089380 No Department of Anesthesiology and Critical Care, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Mohsen Sedighi sedighi1984@yahoo.com 200319475328460089381 200319475328460089381 No Trauma and Injury Research Center, Iran University of Medical Sciences, Tehran, Iran Alireza Amanollahi amanolliahi@iums.ac 200319475328460089382 200319475328460089382 No Trauma and Injury Research Center, Iran University of Medical Sciences, Tehran, Iran Ali Khatibi khatibi@iums.ac 200319475328460089383 200319475328460089383 No Department of Anesthesiology and Critical Care, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Mohammadreza Ghodrati Ghodrati@iums.ac 200319475328460089384 200319475328460089384 No Department of Anesthesiology and Critical Care, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Mohammad Niakan Lahiji niyakanlahiji.m@iums.ac.ir 200319475328460089385 200319475328460089385 Yes Trauma and Injury Research Center, Iran University of Medical Sciences, Tehran, Iran