Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1378
11
1
gregorian
2000
2
1
13
4
online
1
fulltext
en
VASODILATOR EFFECTS OF THE β -AGONIST ISOPRENALINE IN AN EXPERIMENTAL MODEL OF HEART FAILURE
Physiology
Physiology
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
Heart failure is a clinical syndrome characterized by the inability of the heart
to provide nutrient supply to tissues. In 75% of cases, the underlying pathology
causing heart failure in patients with cardiac death is coronary heart disease. A
rabbit model of heart failure with coronary ligation was produced to mimic
coronary heart disease in humans. After producing the model, two arteries and two
veins were investigated in the two groups (control and with coronary ligation).
Arteries and veins were cut as rings and bathed in Krebs solution maintained at 37
DC, and gassed with 95% oxygen and 5% CO
2
, Then all tissues were placed under
different resting tensions and allowed to equilibrate for 1 hour. Then all the tissues
were contracted with U -46619 (0.1 µM) nearly ten minutes before initial application
of isoprenaline. When the U -46619 (0.1 µM)-induced contraction reached a
plateau, concentration-response curves to isoprenaline were obtained. Isoprenaline
was chosen as a vasodilator, it's effect resulting from stimulating beta receptors in
blood vessels. Isoprenaline induced relaxation in all tissues, but the renal artery
was the most sensitive and showed maximum relaxation.20-26 Compared to
acetylcholine, relaxation responses were small and maximum responses observed
in the vena cava, aorta and renal vein were only 10 percent. In all tissues, relaxation
responses to the vasodilator agent isoprenaline showed no significant difference
between control and coronary ligated rabbits 8 weeks after operation.
Heart failure, coronary ligation, isoprenaline.
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http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-375&slc_lang=en&sid=1
MUSTAFA
MOHAMMADI NAGHADEH
20031947532846004546
20031947532846004546
Yes
From the Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, I.R.lran
J.e
McGRATH
20031947532846004547
20031947532846004547
No
the Clinical Research Initiative in Heart Failure, West Medical Building, University of Glasgow, Glasgow G21 8QQ, UK.