Medical Journal of the Islamic Republic Of Iran

en The Effect of Pregabalin on Preoperative Anxiety and Postoperative Pain in Patients Undergoing Percutaneous Nephrolithotomy: A Randomized Controlled Trial Urology and Nephrology Urology and Nephrology Original Research Original Research Background: Percutaneous nephrolithotomy (PCNL) is the preferred surgical technique for treating kidney stones. Preoperative anxiety is a common psychiatric symptom experienced by many patients undergoing surgery. We aimed to evaluate the effects of pregabalin administration on preoperative anxiety and postoperative pain in patients undergoing PCNL.    Methods: This randomized controlled trial included 104 patients who were scheduled for PCNL surgery and were randomly assigned to 1 of the 4 groups: placebo, 75 mg of pregabalin, 150 mg of pregabalin, or 300 mg of pregabalin. The anxiety level was measured using the Hamilton Rating Scale for Anxiety (HRSA), and the postoperative pain was assessed using the visual analog scale (VAS). Methods such as the Wilcoxon Signed Ranks Test was used for the before-after test and the Kruskal Wallis Test was used for between-group time comparisons. The generalized estimation equation (GEE) and Poisson log-linear were used for the link function.    Results: After comparing the different doses of pregabalin to the placebo, no statistically significant relationships were detected (P=0.931 and P=0.886, respectively). In the group-time study of these patients, the pain level in all 4 groups decreased with time. This decrease in pain was statistically significant for most of the groups (P<0.05).    Conclusion: Administering pregabalin before PCNL surgery does not significantly reduce anxiety in patients before the procedure. However, preoperative administration of pregabalin has been found to be beneficial for alleviating postoperative pain in patients who have undergone PCNL surgery, with the optimal dosage of 75 mg pregabalin.   Percutaneous Nephrolithotomy, Perioperative Anxiety, Postoperative Pain, Pregabalin 182 189 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6496-4&slc_lang=en&sid=1 Anahita Ansari Djafari d_ansary@yahoo.com 200319475328460089991 200319475328460089991 No Clinical Research Development Unit of Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Amir Alinejad Khorram amir.alinejad1992@gmail.com 200319475328460089992 200319475328460089992 No Urology Department, Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Seyyed Ali Hojjati sah_hojjati@yahoo.com 200319475328460089993 200319475328460089993 No Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Fayaz mohammad.fayaz.89@gmail.com 200319475328460089994 200319475328460089994 No Health and Social Medicine Department, School of Medicine, Shahed University, Tehran, Iran Amir Hossein Eslami dr.amir.eslami1992@gmail.com 200319475328460089995 200319475328460089995 No Urology Department, Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Maryam Garousi garousi.m@iums.ac.ir 200319475328460089996 200319475328460089996 No Radiation Oncology Department, Iran University of Medical Sciences, Tehran, Iran Saba Faraji s_farajin@sina.tums.ac.ir 200319475328460089997 200319475328460089997 Yes Tehran University of Medical Sciences, Tehran, Iran Elnaz Aghabeiki elnaz.aghabeiki@gmail.com 200319475328460089998 200319475328460089998 No Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), School of Medicine, Iran University of Medical Sciences, Tehran, Iran