en Medical Library and Information Sciences Medical Library and Information Sciences Original Research Original Research <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><b><span style="font-size:9.0pt"><span style="font-style:normal">Background: </span></span></b><span style="font-size:9.0pt"><span style="font-style:normal">Testosterone replacement therapy (TRT) is pivotal in addressing male hypogonadism, yet uncertainties persist regarding its optimal use and long-term ramifications. This study aims to explore the knowledge map of TRT.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Methods:</b> In this bibliometric study, we searched Scopus for relevant keywords from the beginning to 2023. Our inclusion criteria were original articles and reviews and our exclusion criteria were non-English and non-related articles and document types other than original articles and reviews. Excel, VOS viewer, and Science of Science (Sci2) software were used for data synthesis.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Results:</b> From 6712 retrieved articles, 5325 articles were included for analysis. The most productivity belonged to the USA (n=2,570 documents), the United Kingdom (n=476), and Italy (n=339). &ldquo;Journal of Clinical Endocrinology and Metabolism&rdquo; (n=168) had the highest participation in publishing. Also, &quot;Journal of Clinical Endocrinology and Metabolism&quot; and the &quot;Journal of Sexual Medicine&quot; exhibited significant bibliographic coupling with other journals in the TRT field. The research topics of interest were mainly related to hypogonadism, prostate cancer, and erectile dysfunction. Bursting analysis of the title and abstract revealed the TRT research prior to the year 2000 was mainly focused on castration, gonadectomy, growth, and aplastic anemia, while the focus of recent research moved towards libido, cardiovascular events, HIV, geriatric issues, diabetes, bipolar disorder, cancer, transmasculine, and transgender individuals.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Conclusion:</b> This study highlights the growing trend of TRT research over time, with most focus on hypogonadism, prostate cancer, and erectile dysfunction. Insights gleaned from this analysis inform research priorities and resource allocation, facilitating enhanced patient care in androgen deficiency management.</span></span></span></span></span></span></span></span><br> &nbsp; Scientometric, Bibliometric, Knowledge Map, Testosterone Replacement Therapy, TRT, Hypogonadism 950 959 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-3673-6&slc_lang=en&sid=1 Ali Faryabi Faryabi.ali@gmail.com 200319475328460089696 200319475328460089696 No Tehran University of Medical Sciences, Tehran, Iran Hossein Aazami Hossein.aazami@gmail.com 200319475328460089697 200319475328460089697 No Iran University of Medical Sciences, Tehran, Iran Faezeh Norouzi Fanorouzi8@gmail.com 200319475328460089698 200319475328460089698 No Isfahan University of Medical Sciences, Isfahan, Iran Mohammad Reza Fattahi Mrfatahi93@gmail.com 200319475328460089699 200319475328460089699 No Student Research Committee, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Hojat Dehghanbanadaki dehghan.hojat@yahoo.com 200319475328460089700 200319475328460089700 Yes Tehran University of Medical Sciences, Tehran, Iran