en Psychiatry Psychiatry Original Research Original Research <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><b><span style="font-size:9.0pt"><span style="font-style:normal">Background: </span></span></b><span style="font-size:9.0pt"><span style="font-style:normal">Memory is one of the most affected cognitive domains in patients with Bipolar I Disorder, even during periods of euthymia. This study aimed to investigate the relationship between certain clinical and demographic variables and the domains of memory function in euthymic bipolar I patients.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Methods: </b>This cross-sectional study included 100 patients who were confirmed to be euthymic at the time of the research, as indicated by Hamilton Depression Rating Scale scores (HDRS <7) and Young Mania Rating Scale scores (YMRS <12). Recruitment was conducted between March 2021 and March 2022.&nbsp; Their demographic data were collected, and all participants were evaluated for psychiatric comorbidities using the Structured Clinical Interview for DSM-5 (SCID-5-CV). Memory function was assessed using the Wechsler Memory Scale-3rd edition (WMS-3). The correlation between memory function and demographic and clinical variables was analyzed.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Results:</b> The Wechsler Memory Scale total score was significantly associated with the number of hospitalizations, education level, and the number of depressive episodes. Notably, each additional hospitalization (&beta; = -21.70 &plusmn; 8.18) and depressive episode (&beta; = -23.36 &plusmn; 6.86) corresponded to a marked reduction in memory performance. The regression model demonstrated a robust fit, with an R-square value of 0.68.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Conclusion:</b> Memory function is significantly correlated with the number of hospitalizations, level of education, and the number of previous depressive episodes in euthymic Bipolar I patients. This study underscores the importance of these factors in understanding and preventing memory impairment in this patient group.</span></span></span></span></span></span></span></span><br> &nbsp; Bipolar Disorder, Memory Function, Euthymic Phase, Wechsler Memory Scale, Depressive Episodes 270 278 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-9014-1&slc_lang=en&sid=1 Amir Shabani shabani.a@iums.ac.ir 200319475328460089981 200319475328460089981 No Mental Health Research Canter, Psychosocial Health Research Institute, Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Seyed Vahid Shariat vahid.shariat@gmail.com 200319475328460089982 200319475328460089982 No Mental Health Research Canter, Psychosocial Health Research Institute, Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Maryam Noroozian maryam.noroozian.mn@gmail.com 200319475328460089983 200319475328460089983 No Department of Neuropsychiatry and Cognitive Neurology, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran Morteza Naserbakht Naserbakht.m@iums.ac.ir 200319475328460089984 200319475328460089984 No Mental Health Research Canter, Psychosocial Health Research Institute, Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Maryam Mohammadi dr_mohammadimaryam@yahoo.com 200319475328460089985 0009-0006-6128-7174 Yes Mental Health Research Canter, Psychosocial Health Research Institute, Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran