Medical Journal of the Islamic Republic Of Iran

en Peripheral Arterial Disease is Associated with Sensorimotor Peripheral Neuropathy in People with Type 2 Diabetes Endocrinology Endocrinology Original Research Original Research Background: Micro- and macro-vascular complications of diabetes seem to be interconnected. This study aimed to evaluate the association between peripheral arterial diseases (PAD) and diabetic sensorimotor peripheral neuropathy (DSPN).    Methods: This cross-sectional study was conducted among 748 people with type 2 diabetes (T2DM) referred to a tertiary care center between 2017 and 2022. PAD was defined as Ankle-brachial index (ABI) ≤ 0.9. Loss of protective sensation (LOPS) was applied for the detection of DSPN. Logistic  regression analysis was used to determine the association between PAD and DSPN.    Results: The mean age of the participants was 59.6 (±8.8) years, and the median duration of diabetes was 10 (5-16) years. LOPS was detected in 491 individuals (65.6%). ABI ≤ 0.9 was associated with a significantly higher risk of LOPS (OR: 3.65, 95% Confidence Interval (CI): 1.97- 6.74). In addition, every 0.1 decrease in ABI increased the risk of LOPS by 21% (95%CI: 10- 34%). Toe brachial index (TBI) ≤0.7 was also associated with a significantly higher risk of LOPS (OR: 1.77, 95%CI: 1.28- 2.46). Each 0.1 decrease in TBI increased the risk of LOPS by 19% (95%CI: 10- 28%).     Conclusion: PAD is strongly associated with DSPN. Assessment of DSPN could be considered in the presence of PAD.   Peripheral artery disease, Diabetes, Sensorimotor peripheral neuropathy, Ankle-brachial index, Loss of protective sensation 1160 1165 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6674-1&slc_lang=en&sid=1 Nahid Hashemi-Madani nahid.hashemimadani@gmail.com 200319475328460087470 200319475328460087470 No Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran Masoumeh Azadi masumeh.freedom@gmail.com 200319475328460087471 200319475328460087471 No Endocrine Research Center, Institute of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Alireza Khajavi alireza.khajavi.student@gmail.com 200319475328460087472 200319475328460087472 No School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Zahra Emami zemami64@gmail.com 200319475328460087473 200319475328460087473 No Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran Mohammad E. Khamseh khamseh.m@iums.ac.ir 200319475328460087474 200319475328460087474 Yes Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran