en Cardiology Cardiology Original Research Original Research <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><b>&nbsp;&nbsp;</b><b><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp; Background: </span></span></b><span style="font-size:9.0pt"><span style="font-style:normal">While microalbuminuria is established in left heart dysfunction prognostication, its relationship with right ventricular (RV) function remains unclear. We investigated whether microalbuminuria predicts early-stage RV dysfunction in patients with normal coronary arteries.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Methods:</b> This cross-sectional analysis involved 117 patients with angiography-verified non-obstructive CAD. Comprehensive RV echocardiography (including E/e&#39; ratio) and morning urine albumin-creatinine ratio (UACR) measurements were performed. The study patients were categorized into 67 with normal albuminuria (mAlb (-): UACR <30 mg/g) and 50 with microalbuminuria (mAlb (+): UACR 30-300 mg/g). Multivariable logistic regression evaluated microalbuminuria&rsquo;s relationship with RV metrics, adjusting for sex, age, and BMI. A </span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal"><0.05 denoted statistical significance.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Results:</b> The mAlb (+) group demonstrated significantly higher RV E/e&#39; ratios (</span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal">=0.026), persisting after adjustment. Logistic regression revealed that microalbuminuria independently predicted elevated RV filling pressure (OR 2.88, 95% confidence interval 1.22-6.84, </span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal">=0.016). Male sex showed non-significant trends (OR 1.69, </span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal">=0.286). RV systolic dysfunction prevalence was comparable between groups (16.4% overall, p=NS).</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Conclusion:</b> Microalbuminuria independently associates with elevated RV filling pressures in non-obstructive CAD patients, suggesting shared microvascular pathophysiology. This supports albuminuria screening&#39;s potential role in identifying subclinical RV dysfunction, though longitudinal studies are needed to establish causality.</span></span></span></span></span></span></span></span><br> &nbsp; Albuminuria, Right Ventricle, Coronary Vessels 785 791 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-974-10&slc_lang=en&sid=1 Mahdokht Rezaei rezaiemahdokht@yahoo.com 200319475328460092299 0009-0009-1253-9509 No Department of Cardiology, BouAli Hospital, Qazvin University of Medical Sciences, Qazvin, Iran Elham Ebadi e2_md@yahoo.com 200319475328460092300 200319475328460092300 No Department of Cardiology, BouAli Hospital, Qazvin University of Medical Sciences, Qazvin, Iran Abbas Allami allami@qums.ac.ir 200319475328460092301 200319475328460092301 Yes Department of Infectious Diseases, BouAli Hospital, Qazvin University of Medical Sciences, Qazvin, Iran Kimia Rahimi Ardali kimiarahimiardali@gmail.com 200319475328460092302 200319475328460092302 No Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran Shahin Aliakbari aliakbarishahin@gmail.com 200319475328460092303 200319475328460092303 No Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran