en Nephrology Nephrology Original Research Original Research <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><b><span style="font-size:9.0pt"><span style="font-style:normal">Background: </span></span></b><span style="font-size:9.0pt"><span style="font-style:normal">Hemodialysis (HD) patients frequently experience uremic pruritus, a condition that is both irritating and prevalent. Although its pathogenesis is not entirely understood, it is believed to be multifactorial. The objective of this investigation was to evaluate the renal osteodystrophy indices in patients undergoing hemodialysis with and without pruritus.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Methods:</b> This cross-sectional study categorized HD patients in 3 university hospitals in Mashhad, northeast Iran, during 2022 and 2023 into 2 groups: those with and those without pruritus, as determined by the diagnostic criteria. The visual analog scale parameter was employed to evaluate the severity of pruritus. Each patient&#39;s blood urea nitrogen, creatinine, calcium, phosphorus, and intact parathyroid hormone (iPTH) levels were evaluated. The data were analyzed using SPSS software Version 16. An independent sample t test and the Mann-Whitney U test, as well as the Spearman correlation test, were used for analysis.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Results:</b> A total of 120 participants with a mean age of 57.91 &plusmn; 16.03 years were included in the study. The findings showed that the mean blood levels of calcium (</span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal"> < 0.001), phosphorus (</span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal"> < 0.001), creatinine (</span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal"> < 0.001), alkaline phosphatase (</span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal"> = 0.002), and calcium phosphate product (</span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal"> < 0.001) were significantly higher in the pruritic group. However, the mean blood urea nitrogen (</span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal"> = 0.458) and iPTH levels (</span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal"> = 0.139) did not differ significantly between the 2 groups, but there was a significant relationship between iPTH level and the severity of pruritus (</span></span><span style="font-size:9.0pt">P</span><span style="font-size:9.0pt"><span style="font-style:normal"> < 0.001).</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic"><span style="font-size:9.0pt"><span style="font-style:normal">&nbsp;&nbsp; <b>Conclusion:</b> The itching severity in HD patients is substantially correlated with their iPTH levels, and the majority of the indices of renal osteodystrophy are significantly higher in patients with this complication. However, additional studies are suggested.</span></span></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span style="font-style:italic">&nbsp;</span></span></span></span></span></span><br> &nbsp; Renal Osteodystrophy, Hemodialysis, Pruritus, CKD-aP 781 784 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-9209-1&slc_lang=en&sid=1 Dorsa Zeraati dorsazrt77@gmail.com 200319475328460092261 200319475328460092261 No Student Research Committee, MMS.C., Islamic Azad University, Mashhad, Iran Ali Emadzadeh ali_emadzadeh@iau.ac.ir 200319475328460092262 0009-0000-7311-1164 Yes Department of Internal Medicine, MMS.C., Islamic Azad University, Mashhad, Iran Abbas Ali Zeraati zeraatia@mums.ac.ir 200319475328460092263 200319475328460092263 No Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran