en Pediatric Pediatric Original Research Original Research This study was initiated to evaluate the long-term safety, tolerability and efficacy of seizure control of lamotrigine (LTG) in children and adult patients with partial seizures (PS) with or without secondary generalized seizure. A total of 132 patients (age 5-41 years) with treatment-resistant epilepsy received LTG as addon therapy for up to four years. Overall, patients were treated with LTG for 27 -226 weeks. The global assessment of seizure control compared to the three-month period before starting LTG treatment indicated that seizure control was gradually maintained during long-term LTG treatment for up to four years. The medical history of 23 patients who had a significant decrease in the number of seizures with LTG treatment indicated a subjective improvement in behavior, alertness, and quality of life. All 132 patients who received LTG as add-on therapy had used 2- 4 anti-convulsive medications 2-7 years before entering this open continuation study. Patients had 7-45 seizures per month throughout the 3 months before entering this study. The overall decrease in the number of seizures was 58% after patients started receiving LTG. LTG was well tolerated. The majority of adverse effects were classified as being mild in intensity and only 5 patients (4%) were withdrawn from the study due to adverse effects (skin rash). 107 110 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-402&slc_lang=en&sid=1 AZAR FALLAH 20031947532846004641 20031947532846004641 Yes From the Department of Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.