Medical Journal of the Islamic Republic Of Iran

en An Assessment of the Diagnostic Accuracy of Magnetic Resonance Diffusion Kurtosis Imaging in Diagnosing Degenerative Lumbar Spine Disease: A Scoping Review Radiography Radiography Scoping Review Article Background: Degenerative disorders of the lumbar spine are a common cause of chronic pain and disability, particularly in older adults. They involve the progressive degeneration of intervertebral discs, which leads to symptoms such as lower back pain, nerve compression, and neurological deficits. While traditional MRIs are a widely used and effective tool for diagnosing many spinal conditions, including degenerative disorders of the lumbar spine, they do have limitations when it comes to detecting early microstructural changes in the intervertebral discs and other spinal components. This limitation can delay diagnosis and intervention in the early stages of degeneration, which is critical for preventing progression. The scoping review aims to sensitize the current evidence on the diagnostic performance of Diffusion Kurtosis Imaging (DKI) in detecting and characterizing degenerative changes in the lumbar spine.    Methods: Using the Arksey and O'Malley framework, we performed an extensive literature search across Scopus, Embase, and PubMed to identify relevant studies published between January 2010 and 2024. The selection criteria included 3T MRI studies utilizing DKI techniques aimed at evaluating degenerative changes in the lumbar spine.    Results: The total number of studies included in this study was 3 out of 355, where our preliminary findings indicate that the DKI parameters demonstrated an early detection of microstructural changes within the degenerative lumbar spine as compared to the healthy controls. Accordingly, these changes are highly correlated with clinical symptoms and the extent of degeneration observed on  conventional MRI, suggesting that DKI is more sensitive to detecting early microstructural changes.    Conclusion: MR Diffusion Kurtosis Imaging offers a substantial potential for detecting subtle microstructural changes in the lumbar spine degeneration at an early stage, that is crucial for earlier diagnosis and intervention. The integration of DKI sequence into clinical practice could result in an increase in diagnostic accuracy and patient outcomes.   Magnetic Resonance Imaging, Diffusion Kurtosis Imaging, Degenerative Spine, Lumbar Spine 447 455 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-9275-1&slc_lang=en&sid=1 Neil Abraham Barnes neil.mchpmpl2023@learner.manipal.edu 200319475328460091157 0009-0008-7160-8693 No Department of Medical Imaging Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India Winniecia Dkhar winniecia.dkhar@manipal.edu 200319475328460091158 200319475328460091158 Yes Department of Medical Imaging Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India Rajagopal Kadavigere rajagopal.kv@manipal.edu 200319475328460091159 200319475328460091159 No Department of Radiodiagnosis and Imaging, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India Abhimanyu Pradhan abhimanyu.pradhan@manipal.edu 200319475328460091160 200319475328460091160 No Department of Medical Imaging Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India