Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1378
5
1
gregorian
1999
8
1
13
2
online
1
fulltext
en
PREVENTIVE EFFECTS OF VITAMIN A AND ASPIRIN ON UV LIGHT-INDUCED RETINOPATHY IN AN ANIMA L MODEL
Ophthalmology
Ophthalmology
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
In order to identify the effects of vitamin A and aspirin on reducing UV lightinduced
retinopathy, ERG waves were compared before and after UV light
exposure in rabbits. 30 rabbits were divided into 3 groups: the first group received
vitamin A, 50,000 units I.M., single dose, the second group received aspirin, 50 mg/
kg/day PO and the third group did not receive any medication. All three groups
were exposed to UV light generated by three 30 watt lamps for 14 days. Baseline
ERGs were recorded for all rabbits prior to UV light exposure and the second ERG
was taken 14 days after exposure.
The control group showed a 62.6% decrease in voltage amplitude from the
baseline of photopic flicker 30 Hz ERG. This decrease was 28.6% for those who
received vitamin A and only 8.8% for those who received aspirin. Regarding
photopic single flash ERGs, the decrease in the voltage amplitude for control,
vitamin A and aspirin groups was 49.02%,26.14% and 24.83%, respectively.
It was therefore concluded that vitamin A and aspirin have a preventive role on
the side effects of UV light in the rabbit eye retina.
Further studies are needed to elicit the appropriate dosage of aspirin and vitamin
A in preventing the side effects of UV light in the human eye.
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http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-407&slc_lang=en&sid=1
BA
SBAHRIARI
20031947532846004651
20031947532846004651
Yes
From the Dept. of Ophthalmology, Zahedan University of Medical Sciences, Zahedan, IR.Iran.
AM
SALARI
20031947532846004652
20031947532846004652
No