Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1378
5
1
gregorian
1999
8
1
13
2
online
1
fulltext
en
INHIBITORY EFFECT OF KETOTIFEN ON CONTRACTIONS OF RAT ISOLATED BLADDER
Pharmacology
Pharmacology
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
Ketotifen is a benzocycloheptathiophene with a range of pharmacological
activities. The present study was carried out to evaluate the action of ketotifen on
isolated rat bladder contractions induced by KCI and acetylcholine, compared with
the effects of other drugs. Ketotifen (5 µM) reduced the response to acetylcholine
on rat isolated bladder without altering the maximum response and shifted the
acetylcholine concentration-response curve to the right 16 - fold. Ketotifen also
reduced the KCl response, while atropine only inhibited the response to acetylcholine.
Diazoxide inhibited bladder - induced contraction only at high concentration (500
µM). This study shows that ketotifen is a relaxant of isolated rat bladder. As the
inhibition of contractile overactivity of the bladder is the basis of treatment of
bladder instability, provided that a similar effect will be seen in vivo, then ketotifen
may have clinical benefits for treatment of this condition.
Bladder, Ketotifen, Atropine, Diazoxide, Smooth Muscle.
151
155
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-411&slc_lang=en&sid=1
H
SADRAEI
20031947532846004662
20031947532846004662
Yes
From the Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences ,Isfahan, I.R. Iran.
V
HAJHASHEMI
20031947532846004663
20031947532846004663
No