Medical Journal of the Islamic Republic Of Iran

en Fractionated Gamma Knife Surgery: Long-Term Results and Patient Outcomes for Intracranial Lesions Neurosurgery Neurosurgery Original Research Original Research     Background: Fractionated gamma knife surgery (f-GKS) is an effective and safe procedure for treating various intracranial lesions, including pituitary adenomas and meningiomas. It offers noninvasive treatment with short hospitalization periods. This study aims to assess the long-term outcomes of f-GKS in patients at the Iran Gamma Knife Center (IGKC).    Methods: This cross-sectional study examined patients who underwent at least 2 GKS sessions between 2011 and 2018. Lesion sizes in 2-dimensional slices were compared before and after the procedure. Data were analyzed using descriptive statistics in SPSS software Version 22.    Results: The study included 106 patients (32 male, 74 female), with a mean age of 49.95 ± 16.6 years. The follow-up period was 24.98 ± 19.01 months. The most common pathology was meningioma, with f-GKS typically performed 3 times at 1-day intervals. The median change in lesion area was 185.67 mm². Out of 36 patients at the last visit, 26 (72.2%) showed improved prognosis. The maximum radiation dose used was 13.05 ± 5.21 Gy. The pathology coverage was 98.69% ± 2.15%, with a mean and mode of 99%.    Conclusion: In this study, we examined various factors, including lesion levels from brain Magnetic Resonance Imaging findings, patient prognosis, and changes after f-GKS. Our results confirm those of previous studies, highlighting the significant role of noninvasive GKS in improving patient prognosis and reducing tumor size.   Radiosurgery, Gamma Knife Surgery, Fractionated Gamma Knife Surgery, Brain Neoplasms, Meningioma, Skull Base 949 955 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-9333-1&slc_lang=en&sid=1 Farid Kazemi Gazik kazemigazikf@gmail.com 200319475328460093293 200319475328460093293 No Department of Neurosurgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Taghi Aghajanloo aghajanloo.t@iums.ac.ir 200319475328460093294 0009-0008-7404-8265 No Department of Orthopedic Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Narges Mirzania Nargesmirzania@gmail.com 200319475328460093295 0009-0000-2985-9140 Yes Department of Oral and Maxillofacial Radiology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran Ali Ariyaei Motahar ali.ariyaeimotahar.md@gmail.com 200319475328460093296 0009-0008-8253-5709 No School of Medicine, Iran University of Medical Sciences, Tehran, Iran Amin Jahanbakhshi jahanbakhshi.a@iums.ac.ir 200319475328460093297 200319475328460093297 No Skull Base Research Center, Iran University of Medical Sciences, Tehran, Iran