Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1377
11
1
gregorian
1999
2
1
12
4
online
1
fulltext
en
THE VALUE OF IMMUNOLOGICAL TESTS IN PREDICTING PREGNANCY OUTCOME
Immunology
Immunology
Original Research
Original Research
In addition to ultrasonographic monitoring of folliculogenesis, urinary luteinizing
hormone testing, luteal phase endometrial biopsy, serum antiphospholipid
antibodies, etc., immunologic tests are recently being used to evaluate reproductive
disorders. In this study, sharing of HLA-A, B, C and DR antigens and the presence
of antipaternal cytotoxic antibody (APCA) was assessed using microcytotoxicity
method.
Subjects of the study were 103 infertile couples, 47 fertile couples with 2-3
children and 123 couples with recurrent spontaneous abortions (RSA).
The results showed that the presence of antipatemal cytotoxic antibody is
associated with fertility rather than infertility (p<0.0001), but sharing of HLA
antigens failed to show any significant difference between infertile and fertile
couples or couples who experienced spontaneous abortions compared with normal
couples. Therefore it appears that HLA antigen sharing is not associated with
pregnancy outcome and other antigen(s) may be involved in this process. Assessment
of APCA could be useful in predicting the pregnancy outcome.
APCA; HLA-antigen; RSA; fertile.
309
312
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-430&slc_lang=en&sid=1
A
A. REZAEI
20031947532846004709
20031947532846004709
Yes
From the Department of Immunology, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.