Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1377
11
1
gregorian
1999
2
1
12
4
online
1
fulltext
en
DI AGNOSTIC VAL UE OF SUBL INGUAL NITROGLYCERIN TILT TEST: COMPARISON WITH THE STANDARD ISOPROTERENOL TILT TEST
Heart
Heart
Original Research
Original Research
Sublingual nitroglycerin (TNG) has been introduced as a promising provocative
agent for tilt table testing, but it has not been compared directly with the standard
isoproterenol (ISO) infusion test previously. We tried to assess the diagnostic value
and safety of TNG tilt testing as compared with ISO infusion in patients with
unexplained syncope.
TNG and ISO tilt tests were performed in two successive days on a random basis
for both cases and controls. 65 consecutive patients with unexplained syncope after
thorough work-up and 20 healthy volunteers were recruited into the study. Positive
responses were observed in 20 patients (31 %) during the passive phase, 25 (55% of
cases or 38% of total) during the TNG phase and 26 (58% or40% of total) during the
ISO phase. In the control group, positive responses during the passive, TNG and ISO
phases occurred in 1,1 and 2 cases, respectively. The sensitivity and specificity of the
tests can be summarized as 69% and 90% respectively for the TNG test versus 71 %
and 85% respectively for the ISO test. Owing to discordant responses in 75% of the
cases, the sequential use of the tests (if one is negative) would increase the sensitivity
to 89% while decreasing the specificity slightly (to 80%). Side effects were also less
frequent with TNG. We conclude that sublingual TNG testing is an effective and safe
alternative to the ISO infusion test and can be used as a complementary test.
Syncope, Tilt table test, Isoproterenol, Nitroglycerin.
325
328
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-433&slc_lang=en&sid=1
SAEED
ORAII
Oraii@ rhc. ac. ir.
20031947532846004717
20031947532846004717
Yes
From the Cardiology Department of Shahid Rajaii Heart Hospital. Iran University of Medical Sciences. Tehran. I.R. Iran
MAJID
MALEKI
20031947532846004718
20031947532846004718
No
MEHRNOOSH
MINOOIl
20031947532846004719
20031947532846004719
No
PARIVASH
KAFAII
20031947532846004720
20031947532846004720
No
MAHMOOD
EFTEKHARZADEH
20031947532846004721
20031947532846004721
No