Volume 11, Issue 4 (2-1998)                   Med J Islam Repub Iran 1998 | Back to browse issues page

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KARAMIZADEH Z, AMIRHAKIMI G. EFFEC T OF HUMAN GROWTH HORMONE TREATMEN T IN CHILDREN WI TH GROWTH HORMONE DEFICIENCY, TURNER'S SYNDROME AND ACHONDROPLASIA: A COMPARISON OF DOSE FREQUENCY AND ROU TE OF ADMINIS1RATION. Med J Islam Repub Iran 1998; 11 (4) :303-306
URL: http://mjiri.iums.ac.ir/article-1-1071-en.html
EFFEC T OF HUMAN GROWTH HORMONE TREATMEN T IN CHILDREN WI TH GROWTH HORMONE DEFICIENCY, TURNER'S SYNDROME AND ACHONDROPLASIA: A COMPARISON OF DOSE FREQUENCY AND ROU TE OF ADMINIS1RATION
Z KARAMIZADEH , GH AMIRHAKIMI
From the Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
Abstract:   (4298 Views)
Recombinant human growth hormone (hGH) was given for 6 months or longer to 68 patients with GH deficiency, 6 with Turner's syndrome and 5 with achondroplasia, during 1986-1994 in a prospective study. The total weekly administered dose of GH was 0.6 u/kg. By random sampling, 29 of 68 GH deficient patients (42.6%) received twice weekly (2 iw) intramuscular (im) injections, 17 (25%) received twice weekly subcutaneous (sc) injections and 22 received hGH 6 times per week (6 iw) sc during the first 6 months of therapy. In the GH deficient group the mean pretreatment height velocity was 4 ± 1.2 cm! yr (mean ±SD). The mean velocity during the first 6 months of treatment was 8.7 ± 2.3 cm/yr (p<0.0005), regardless of the frequency and type of GH administration. During the second 6 months and second year of treatment, the mean growth rates were 7.7 ± 2.2 and 6.7 ± 2.2 cm, respectively. The mean increase in height during the first 6 months of therapy for the 2 iw im group (7.7 ± 1.6 cm) compared with the 2 iw sc group (7.6 ± 2.1) did not exhibit any significant difference (0.8
Keywords: Growth hormone deficiency, Turner\'s syndrome, Achondroplasia
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Type of Study: Original Research | Subject: Pediatric
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