Volume 10, Issue 1 (5-1996)                   Med J Islam Repub Iran 1996 | Back to browse issues page


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NIKNAM H, MANSOORI P, NIKBIN B, DANESHPAJOUH M, AMIRKHANI A, ALIMOHAMMADIAN M. HLA CLASS I IN IRANIAN P SORIATIC PATIENTS. Med J Islam Repub Iran. 1996; 10 (1) :37-41
URL: http://mjiri.iums.ac.ir/article-1-1216-en.html

From the Department of Immunology, Pasteur Institute, Tehran
Abstract:   (1847 Views)
The association of HLA and disease varies in different populations. We have . studied the association of HLA class I in Iranian psoriatic patients, in order to compare this association with other reports. Fifty-one Iranian patients with psoriasis were HLA typed. The frequency of HLA antigens in patients and patient subgroups, based on clinical patterns, age of onset, family history and provocative factors, were compared with each other and with normal controls. The results indicate that the disease is strongly associated with HLA-Cw6 (chi-square, corrected P-value (Pc)≤0.0009), and negatively associated with Cw3 (Pc≤ 0.00009 and Pc≤ 0.03, respectively). Psoriatic patients with early onset disease and non-pustular psoriasis (NPP) showed a more significant association with HLA-Cw6 (Pc≤ 0.0004 and Pc≤ 0.0003, respectively). There was no statistically significant relationship between the presence of a positive family history and early onset of disease.
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Type of Study: Original Research | Subject: Immunology