Volume 7, Issue 2 (8-1993)                   Med J Islam Repub Iran 1993 | Back to browse issues page

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MOSHTAGHIE A. HOW ALUMINIUM IS TAKEN U P BY RED BLOOD CELLS: A STUD Y IN RELATION TO H YP OCHROMIC MICROC YTIC ANEMIA IN HEMODIALYZED PATIENTS. Med J Islam Repub Iran. 1993; 7 (2) :87-93
URL: http://mjiri.iums.ac.ir/article-1-1439-en.html
From the Dept of Biochemistry. School of Pharmacy, Isfahan University of Medical Sciences. Isfahan, Islamic Republic of Iran.
Abstract:   (2301 Views)
Investigation of aluminium uptake by human erythrocytes was the major aim of this study. Packed red blood cells were incubated in Earle's medium (pH 7.4) containing varying concentrations of aluminium (0-160 /lg/J) as AIK(SO.), and aluminium content of the cells were determined using flameless atomic absorption. There was significant increase in aluminium content of the cells. Addition of 5 mM glucose caused an elevation of red cell aluminium, whereas depletion of red cells from ATP caused a marked reduction in aluminium uptake. Both ouabain and vanadate, when added to the medium, caused a significant reduction in aluminium uptake in line with a decrease in ATPase activity.
Full-Text [PDF 645 kb]   (1207 Downloads)    
Type of Study: Original Research | Subject: Clinical Biochemistry

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