JAAFARI M, IZADYAR M, RAKHSHAN M, FARHOUDC A H, ZANDIEH T, BABAl G. A STUDY OF THE INTRACELLULAR KILLING OF THE PERIPHERAL BLOOD NEUTROPHILS IN β- THALASSEMIA MAJOR PATIENTS. Med J Islam Repub Iran 1992; 6 (2) :135-138
URL:
http://mjiri.iums.ac.ir/article-1-1494-en.html
From the' Tarbiat Modarres University Tehran, Islamic Republic of Iran.
Abstract: (4376 Views)
52 β- thalassemia major patients were studied. Their ages ranged from
two to 20 years. The group consisted of 22 girls and 30 boys. Candida
intracellular killing and NBT (nitroblue tetrazolium) tests were performed
on the peripheral blood neutrophils of these patients.
Average results of the intracellular killing test was within normal range
for the patients, but showed an appreciable decrease in comparison with the
results of the normal control tests (50 normal persons of the same age group
were tested as normal controls. This decrease was more pronounced in those
patients who had undergone splenectomy.
A converse relationship was observed between the results of the
patients' intracellular killing and their serum ferritin level and age.
Average results of the patients' NBT tests showed an increase in
comparison with those of the control group. The average results for the
patients who had their spleens removed due to hypersplenism was the same
as in those who had normal spleens and had no relation to the serum ferritin
level but did show a moderate relationship with the age of the patients.
A suggestion that can be put forth is the likelihood that intracellular
killing of peripheral blood neutrophils in the β- thalassemia patients is
conductive to the determination of those with greater susceptibility to
infection.