Volume 3, Issue 1 And 2 (8-1989)                   Med J Islam Repub Iran 1989 | Back to browse issues page

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HAGHIGHI B, ANI M, ZAKERI S. INHIBITION OF HUMAN ERYTHROCYTE GLUCOSE 6-PHOSPHATE DEHYDROGENASE ACTIVITY BY DEHYDROEPIANDROSTERONE AND RELATED STEROIDS.. Med J Islam Repub Iran 1989; 3 (1 and 2) :75-78
URL: http://mjiri.iums.ac.ir/article-1-1604-en.html
INHIBITION OF HUMAN ERYTHROCYTE GLUCOSE 6-PHOSPHATE DEHYDROGENASE ACTIVITY BY DEHYDROEPIANDROSTERONE AND RELATED STEROIDS.
B HAGHIGHI , M ANI , S ZAKERI
From the Department of Biochemistry, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Islamic Reupublic of Iran.
Abstract:   (3944 Views)
The inhibitory effects of several steroids on G6PD activity using intact erythrocytes are reported. Incubation of whole blood with dehydroepiandrosterone (DHEA) resulted in 42% and 12% inhibition in the enzyme activity in the presence and absence of oxygen, respectively. Addition of epinephrine and/or aminophylline into the incubation medium caused further enzyme inhibition suggesting a possible involvement of cAMP in the mechanism by which G6PD activity is inhibited in the system used. The activity of the enzyme was also inhibited by testosterone propionate (11 %), progesterone (25%), and estradiol (15%) at their physiological concentrations. The data obtained provides further evidence for the possible regulatory effects of steroids, particulary DHEA, on G6PD activity.
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Type of Study: Original Research: Basic Science in Medicine | Subject: Clinical Biochemistry
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