Volume 27, Issue 4 (Published 8 October 2013)                   Med J Islam Repub Iran 2013 | Back to browse issues page

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Aziz Jalali M, Jafari B, Isfahani M, Nilforoushzadeh M A. Treatment of segmental vitiligo with normal-hair follicle autograft. Med J Islam Repub Iran. 2013; 27 (4) :210-214
URL: http://mjiri.iums.ac.ir/article-1-1957-en.html
Associate Professor of Dermatology Skin and Stem Cell Research Center, Tehran University ofMedical Sciences, Tehran, Iran. , mohammadalinilforoushzadeh@yahoo.com
Abstract:   (1883 Views)

Background: Segmental vitiligo is a small subset albeit persistent form of focal vitiligo with dermatomal distribution and resistant to medical therapy. In recent years, surgical therapy as hair follicle autograft transplantation has been a hot topic in management of segmental vitiligo. In this study, we evaluated the efficacy of this method in segmental vitiligo lesions.


Methods: The study recruited 10 patients who suffered from resistant segmental vitiligo to evaluate the effect of transplantation of pigmented hair follicles on re-pigmentation of the affected area. In this method, one or two punched-biopsy skin sample with a diameter of 5mm were harvested from occipital area of the scalps. Grafts were trimmed and divided into the follicular segments with at least one follicle in the interior and then inserted in the depigmented areas. Follow-up plan studies were scheduled to evaluate presence of pigmentation in the perifollicular areas.


Results: After 2 weeks, re-pigmentation was detectable surrounding the grafted hair follicles in 60 % of the cases. After 6 months, all of the patients had detectable re-pigmented area of about 2-9 mm.


Conclusion: giving the surprising result of the study, hair follicle autograft transplant is an effective treatment option in the persistent segmental vitiligo.

Full-Text [PDF 204 kb]   (1105 Downloads)    
Type of Study: Original Research | Subject: Dermatology

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